Response of factor X deficiency to darutumumab in the treatment of AL amyloidosis: a novel finding.
genetics
haematology (incl blood transfusion)
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
07 Apr 2021
07 Apr 2021
Historique:
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
15
5
2021
Statut:
epublish
Résumé
We report a case of progressive light-chain amyloidosis (otherwise known as AL amyloidosis) with acquired factor X (aFX) deficiency with a complete haematological response and rapid normalisation of FX levels following daratumumab monotherapy. To our knowledge, this is the first case report documenting successful treatment with daratumumab of aFX deficiency secondary to AL amyloidosis. The patient responded well to this therapy, with excellent symptomatic and quality of life improvements as well as a reduction in bleeding manifestations. This case highlights the value in considering daratumumab treatment when AL amyloidosis is complicated by FX deficiency.
Identifiants
pubmed: 33827877
pii: 14/4/e240631
doi: 10.1136/bcr-2020-240631
pmc: PMC8030679
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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