Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal.

Animals Glucose / metabolism Hyperglycemia / metabolism Hypothalamus / cytology Male Mice Mice, Inbred C57BL Neurons / metabolism Pro-Opiomelanocortin / metabolism Receptor, Melanocortin, Type 3 / genetics Synaptic Potentials
hyperglycemia hypothalamus ventromedial nucleus

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
13 04 2021
Historique:
entrez: 8 4 2021
pubmed: 9 4 2021
medline: 30 11 2021
Statut: ppublish

Résumé

The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons that control these distinct physiologic processes are largely unknown. Here, we show that melanocortin 3 receptor (

Identifiants

DOI: 10.1073/pnas.2103090118 PMID: 33827930 PMC: PMC8053962
pubmed: 33827930
pii: 2103090118
doi: 10.1073/pnas.2103090118
pmc: PMC8053962
pii:
doi:

Substances chimiques

Mc3r protein, mouse 0
Receptor, Melanocortin, Type 3 0
Pro-Opiomelanocortin 66796-54-1
Glucose IY9XDZ35W2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104999
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008322
Pays : United States

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: NovoNordisk provides research grant support to D.P.O. and M.G.M. Ionis Pharmaceuticals provides grant support to M.G.M.

Références

J Med Chem. 2000 Dec 28;43(26):4998-5002
pubmed: 11150170
J Biol Chem. 2011 Nov 25;286(47):40771-81
pubmed: 21984834
J Physiol. 2016 Sep 15;594(18):5285-301
pubmed: 27126579
Diabetes. 2009 Dec;58(12):2757-65
pubmed: 19752162
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2073-82
pubmed: 27001850
Trends Endocrinol Metab. 2013 Dec;24(12):616-24
pubmed: 24063974
Endocrinology. 2019 Feb 1;160(2):343-358
pubmed: 30541071
J Clin Invest. 2020 Jun 1;130(6):2943-2952
pubmed: 32134398
Cell Metab. 2010 Apr 7;11(4):286-97
pubmed: 20374961
Sci Rep. 2020 Mar 26;10(1):5546
pubmed: 32218485
Diabetes. 2001 Dec;50(12):2673-81
pubmed: 11723049

Auteurs

Amy K Sutton (AK)

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.

Paulette B Goforth (PB)

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109.

Ian E Gonzalez (IE)

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.

James Dell'Orco (J)

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.
ORCID: 0000-0001-8565-7535

Hongjuan Pei (H)

Division of Endocrinology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109.

Martin G Myers (MG)

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.

David P Olson (DP)

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109; dpolson@med.umich.edu.
Division of Endocrinology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109.
ORCID: 0000-0001-9249-7760

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Cellules › Neurones › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Pro-opiomélanocortine › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 3 › Melanocortin 3 receptor-expressing neurons in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Melanocortin 3 receptor-expressing neurons in...