Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1.
LTD
LTP
inhibitor-2
neurabin
protein phosphatase 1
synaptic transmission
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
received:
11
09
2020
revised:
08
02
2021
accepted:
09
02
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
18
8
2021
Statut:
ppublish
Résumé
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1). PP1 has three isoforms (α, β, and γ, encoded by three different genes), which are regulated by a vast number of interacting subunits that define their enzymatic substrate specificity. In this review, we discuss evidence showing that PP1 regulates synaptic transmission and plasticity, as well as presenting novel models of PP1 regulation suggested by recent experimental evidence. We also outline the required targeting of PP1 by neurabin and spinophilin to achieve substrate specificity at the synapse to regulate AMPAR and NMDAR function. We then highlight the role of inhibitor-2 in regulating PP1 function in plasticity, including its positive regulation of PP1 function
Identifiants
pubmed: 33827970
pii: 41/14/3040
doi: 10.1523/JNEUROSCI.2026-20.2021
pmc: PMC8026358
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Protein Phosphatase 1
EC 3.1.3.16
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3040-3050Subventions
Organisme : NIMH NIH HHS
ID : R01 MH109719
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047270
Pays : United States
Organisme : NIDA NIH HHS
ID : P30 DA018343
Pays : United States
Organisme : NIMH NIH HHS
ID : F30 MH122046
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066508
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062306
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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