Case Series: Development of Polyps as a Late Effect After Total Body Irradiation-based Hematopoietic Cell Transplantation in Children With High-risk Leukemia.
Adolescent
Age of Onset
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Infant
Leukemia
/ pathology
Male
Polyps
/ etiology
Prognosis
Retrospective Studies
Transplantation Conditioning
Whole-Body Irradiation
/ adverse effects
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
17
07
2020
accepted:
15
02
2021
pubmed:
9
4
2021
medline:
6
1
2022
entrez:
8
4
2021
Statut:
ppublish
Résumé
Advancements in hematopoietic cell transplantation (HCT) have led to increased survivorship rates in many childhood diseases. However, this growing group of long-term survivors face a myriad of late effects. There are currently limited guidelines for surveillance of gastrointestinal polyps for pediatric transplant patients. Here we describe 5 patients undergoing HCT with total body irradiation-based conditioning regimens for leukemia who developed symptomatic polyps a median of 4.5 (range: 0.75 to 5.75) years after HCT. Because of limited surveillance guidelines in children, we conclude that the development of new or progressive symptoms related to the gastrointestinal tract deserves prompt recognition and evaluation.
Identifiants
pubmed: 33828034
doi: 10.1097/MPH.0000000000002152
pii: 00043426-202111000-00032
pmc: PMC8492786
mid: NIHMS1682045
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1159-e1163Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001436
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
R.P. has served on an advisory board for Orchard Therapeutics. The remaining authors declare no conflict of interest.
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