Analysis of the Peripapillary Choroidal Vascular Characteristics in Papilledema Associated with Pseudotumor Cerebri.
Journal
Optometry and vision science : official publication of the American Academy of Optometry
ISSN: 1538-9235
Titre abrégé: Optom Vis Sci
Pays: United States
ID NLM: 8904931
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
pubmed:
9
4
2021
medline:
10
7
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
Choroidal vascularity index measured by image binarization method from peripapillary optical coherence tomography sections has been found significantly lower in papilledema patients than healthy controls. The purpose of this study was to compare peripapillary choroidal parameters in papilledema patients with control subjects. Peripapillary spectral domain optical coherence tomography scans of 34 patients with papilledema and 34 healthy controls are acquired for the study. Images are binarized with the ImageJ software (National Institutes of Health, Bethesda, MD) to calculate total choroidal area, stromal area, luminal area, and choroidal vascularity index. Total choroidal area, luminal area, and choroidal vascularity were significantly lower in papilledema patients compared with healthy controls on right (1.343 ± 0.286 vs. 1.694 ± 0.344, P < .001; 0.880 ± 0.209 vs. 1.167 ± 0.255, P < .001; 65.28 ± 2.99% vs. 68.68 ± 2.81%, P < .001, respectively) and left eyes (1.376 ± 0.308 vs. 1.647 ± 0.339, P < .001; 0.899 ± 0.231 vs. 1.134 ± 0.237, P < .001; 64.92 ± 3.44 vs. 68.84 ± 3.23, P < .001, respectively). No difference was found between active and remitted stages of papilledema in terms of choroidal parameters. Peripapillary total choroidal area, luminal area, and choroidal vascularity index are significantly reduced in patients with papilledema. These parameters might be beneficial tools for evaluating choroidal vascularity in papilledema quantitatively and differential diagnosis for optic disc edema.
Identifiants
pubmed: 33828044
doi: 10.1097/OPX.0000000000001671
pii: 00006324-202104000-00003
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-333Informations de copyright
Copyright © 2021 American Academy of Optometry.
Déclaration de conflit d'intérêts
Conflict of Interest Disclosure: None of the authors have reported a financial conflict of interest.
Références
Friedman DI, Jacobson DM. Diagnostic Criteria for Idiopathic Intracranial Hypertension. Neurology 2002;59:1492–5.
Friedman DI, Liu GT, Digre KB. Revised Diagnostic Criteria for the Pseudotumor Cerebri Syndrome in Adults and Children. Neurology 2013;81:1159–65.
Hayreh SS. Pathogenesis of Optic Disc Edema in Raised Intracranial Pressure. Prog Retin Eye Res 2016;50:108–44.
Margolin E. The Swollen Optic Nerve: An Approach to Diagnosis and Management. Pract Neurol 2019;19:302–9.
Patterson DF, Ho ML, Leavitt JA, et al. Comparison of Ocular Ultrasonography and Magnetic Resonance Imaging for Detection of Increased Intracranial Pressure. Front Neurol 2018;9:278.
Karam EZ, Hedges TR. Optical Coherence Tomography of the Retinal Nerve Fibre Layer in Mild Papilloedema and Pseudopapilloedema. Br J Ophthalmol 2005;89:294–8.
Chiang J, Wong E, Whatham A, et al. The Usefulness of Multimodal Imaging for Differentiating Pseudopapilloedema and True Swelling of the Optic Nerve Head: A Review and Case Series. Clin Exp Optom 2015;98:12–24.
Lee YA, Tomsak RL, Sadikovic Z, et al. Use of Ocular Coherence Tomography in Children with Idiopathic Intracranial Hypertension—a Single-center Experience. Pediatr Neurol 2016;58:101–6.e1.
Leung CK, Cheung CY, Weinreb RN, et al. Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography: A Variability and Diagnostic Performance Study. Ophthalmology 2009;116:1257–63, 1263.e1–2.
Spaide RF, Koizumi H, Pozzoni MC. Enhanced Depth Imaging Spectral-domain Optical Coherence Tomography. Am J Ophthalmol 2008;146:496–500.
Agrawal R, Salman M, Tan KA, et al. Choroidal Vascularity Index (cvi)—a Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? PLoS One 2016;11:e0146344.
Sonoda S, Sakamoto T, Yamashita T, et al. Luminal and Stromal Areas of Choroid Determined by Binarization Method of Optical Coherence Tomographic Images. Am J Ophthalmol 2015;159:1123–31.e1.
Agrawal R, Gupta P, Tan KA, et al. Choroidal Vascularity Index as a Measure of Vascular Status of the Choroid: Measurements in Healthy Eyes from a Population-based Study. Sci Rep 2016;6:21090.
Agrawal R, Jain M, Khan R, et al. Choroidal Structural Changes in Sympathetic Ophthalmia on Swept-source Optical Coherence Tomography. Ocul Immunol Inflamm 2019;1–6.
Suh MH, Park JW, Khandelwal N, et al. Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy. Invest Ophthalmol Vis Sci 2019;60:3768–75.
Wei X, Ting DSW, Ng WY, et al. Choroidal Vascularity Index: A Novel Optical Coherence Tomography Based Parameter in Patients with Exudative Age-related Macular Degeneration. Retina 2017;37:1120–5.
Pellegrini M, Giannaccare G, Bernabei F, et al. Choroidal Vascular Changes in Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy. Am J Ophthalmol 2019;205:43–9.
Pellegrini M, Veronese C, Bernabei F, et al. Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome. Ocul Immunol Inflamm 2019;1–6.
Inam O, Arat YO, Yavas GF, et al. Retinal and Choroidal Optical Coherence Tomography Findings of Carotid Cavernous Fistula. Am J Ophthalmol 2019;206:264–73.
Frisen L. Swelling of the Optic Nerve Head: A Staging Scheme. J Neurol Neurosurg Psychiatry 1982;45:13–8.
Bousquet E, Khandelwal N, Seminel M, et al. Choroidal Structural Changes in Patients with Birdshot Chorioretinopathy. Ocul Immunol Inflamm 2019;1–6.
Agin A, Kadayifcilar S, Sonmez HE, et al. Evaluation of Choroidal Thickness, Choroidal Vascularity Index and Peripapillary Retinal Nerve Fiber Layer in Patients with Juvenile Systemic Lupus Erythematosus. Lupus 2019;28:44–50.
Iovino C, Au A, Hilely A, et al. Evaluation of the Choroid in Eyes with Retinitis Pigmentosa and Cystoid Macular Edema. Invest Ophthalmol Vis Sci 2019;60:5000–6.
Lee B, Ahn J, Yun C, et al. Variation of Retinal and Choroidal Vasculatures in Patients with Age-related Macular Degeneration. Invest Ophthalmol Vis Sci 2018;59:5246–55.
Park Y, Cho KJ. Choroidal Vascular Index in Patients with Open Angle Glaucoma and Preperimetric Glaucoma. PLoS One 2019;14:e0213336.
Koh LH, Agrawal R, Khandelwal N, et al. Choroidal Vascular Changes in Age-related Macular Degeneration. Acta Ophthalmol 2017;95:e597–601.
Guduru A, Abdul Rasheed M, Goud A, et al. Choroidal Vascularity in Non-arteritic Anterior Ischaemic Optic Neuropathy. Neuroophthalmology 2019;43:305–9.
Park JW, Suh MH, Agrawal R, et al. Peripapillary Choroidal Vascularity Index in Glaucoma—a Comparison between Spectral-domain OCT and OCT Angiography. Invest Ophthalmol Vis Sci 2018;59:3694–701.
Lee KM, Kim JM, Lee EJ, et al. Anterior Optic Nerve Head Perfusion Is Dependent on Adjacent Parapapillary Choroidal Perfusion. Sci Rep 2019;9:10999.
Mittra RA, Sergott RC, Flaharty PM, et al. Optic Nerve Decompression Improves Hemodynamic Parameters in Papilledema. Ophthalmology 1993;100:987–97.
Lovasik JV, Kergoat H, Riva CE, et al. Choroidal Blood Flow during Exercise-induced Changes in the Ocular Perfusion Pressure. Invest Ophthalmol Vis Sci 2003;44:2126–32.
Polska E, Simader C, Weigert G, et al. Regulation of Choroidal Blood Flow during Combined Changes in Intraocular Pressure and Arterial Blood Pressure. Invest Ophthalmol Vis Sci 2007;48:3768–74.
Fard MA, Sahraiyan A, Jalili J, et al. Optical Coherence Tomography Angiography in Papilledema Compared with Pseudopapilledema. Invest Ophthalmol Vis Sci 2019;60:168–75.
Tuntas Bilen F, Atilla H. Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography in Idiopathic Intracranial Hypertension. J Neuroophthalmol 2019;39:319–23.
Vupparaboina KK, Dansingani KK, Goud A, et al. Quantitative Shadow Compensated Optical Coherence Tomography of Choroidal Vasculature. Sci Rep 2018;8:6461.