Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
07 04 2021
Historique:
received: 22 07 2020
accepted: 23 03 2021
entrez: 8 4 2021
pubmed: 9 4 2021
medline: 11 11 2021
Statut: epublish

Résumé

Microcirculatory dysfunction occurs early in cardiovascular disease (CVD) development. Acute myocardial infarction (MI) is a late consequence of CVD. The conjunctival microcirculation is readily-accessible for quantitative assessment and has not previously been studied in MI patients. We compared the conjunctival microcirculation of acute MI patients and age/sex-matched healthy controls to determine if there were differences in microcirculatory parameters. We acquired images using an iPhone 6s and slit-lamp biomicroscope. Parameters measured included diameter, axial velocity, wall shear rate and blood volume flow. Results are for all vessels as they were not sub-classified into arterioles or venules. The conjunctival microcirculation was assessed in 56 controls and 59 inpatients with a presenting diagnosis of MI. Mean vessel diameter for the controls was 21.41 ± 7.57 μm compared to 22.32 ± 7.66 μm for the MI patients (p < 0.001). Axial velocity for the controls was 0.53 ± 0.15 mm/s compared to 0.49 ± 0.17 mm/s for the MI patients (p < 0.001). Wall shear rate was higher for controls than MI patients (162 ± 93 s

Identifiants

pubmed: 33828174
doi: 10.1038/s41598-021-87315-7
pii: 10.1038/s41598-021-87315-7
pmc: PMC8027463
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7660

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Auteurs

Paul F Brennan (PF)

Department of Cardiology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK. paul.brennan@belfasttrust.hscni.net.
Biomedical Sciences Research Institute, Ulster University, Coleraine, UK. paul.brennan@belfasttrust.hscni.net.

Andrew J McNeil (AJ)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

Min Jing (M)

Nanotechnology and Integrated Bioengineering Centre (NIBEC), Ulster University, Jordanstown, UK.

Agnes Awuah (A)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

Julie S Moore (JS)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

Jonathan Mailey (J)

Department of Cardiology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK.

Dewar D Finlay (DD)

Nanotechnology and Integrated Bioengineering Centre (NIBEC), Ulster University, Jordanstown, UK.

Kevin Blighe (K)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

James A D McLaughlin (JAD)

Nanotechnology and Integrated Bioengineering Centre (NIBEC), Ulster University, Jordanstown, UK.

M Andrew Nesbit (MA)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

Emanuele Trucco (E)

VAMPIRE project, Computing (SSEN), University of Dundee, Dundee, UK.

Tara C B Moore (TCB)

Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.

Mark S Spence (MS)

Department of Cardiology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK.

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