Hepatitis E in solid organ transplant recipients: A systematic review and meta-analysis.
Hepatitis E virus
Hepatitis E virus infection
Prevalence
Solid organ transplant
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
28 Mar 2021
28 Mar 2021
Historique:
received:
19
12
2020
revised:
17
01
2021
accepted:
12
03
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Hepatitis E virus (HEV) infection is underdiagnosed due to the use of serological assays with low sensitivity. Although most patients with HEV recover completely, HEV infection among patients with pre-existing chronic liver disease and organ-transplant recipients on immunosuppressive therapy can result in decompensated liver disease and death. To demonstrate the prevalence of HEV infection in solid organ transplant (SOT) recipients. We searched Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible articles through October 2020. The inclusion criteria consisted of adult patients with history of SOT. HEV infection is confirmed by either HEV-immunoglobulin G, HEV-immunoglobulin M, or HEV RNA assay. Of 563 citations, a total of 22 studies ( HEV infection is common in SOT recipients, particularly in middle-income countries. The prevalence of HEV infection in lung transplant recipients is considerably less common than other organ transplants. More studies examining the clinical impacts of HEV infection in SOT recipients, such as graft failure, rejection, and mortality are warranted.
Sections du résumé
BACKGROUND
BACKGROUND
Hepatitis E virus (HEV) infection is underdiagnosed due to the use of serological assays with low sensitivity. Although most patients with HEV recover completely, HEV infection among patients with pre-existing chronic liver disease and organ-transplant recipients on immunosuppressive therapy can result in decompensated liver disease and death.
AIM
OBJECTIVE
To demonstrate the prevalence of HEV infection in solid organ transplant (SOT) recipients.
METHODS
METHODS
We searched Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible articles through October 2020. The inclusion criteria consisted of adult patients with history of SOT. HEV infection is confirmed by either HEV-immunoglobulin G, HEV-immunoglobulin M, or HEV RNA assay.
RESULTS
RESULTS
Of 563 citations, a total of 22 studies (
CONCLUSION
CONCLUSIONS
HEV infection is common in SOT recipients, particularly in middle-income countries. The prevalence of HEV infection in lung transplant recipients is considerably less common than other organ transplants. More studies examining the clinical impacts of HEV infection in SOT recipients, such as graft failure, rejection, and mortality are warranted.
Identifiants
pubmed: 33828397
doi: 10.3748/wjg.v27.i12.1240
pmc: PMC8006097
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1240-1254Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declared no potential conflicts of interest.
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