Comparison of the Impact of Zika and Dengue Virus Infection, and Other Acute Illnesses of Unidentified Origin on Cognitive Functions in a Prospective Cohort in Chiapas Mexico.
cognition
communicable diseases
dengue virus infection
humans
memory
mental status and dementia tests
montreal cognitive assessment
zika virus infection
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
11
2020
accepted:
22
02
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
9
4
2021
Statut:
epublish
Résumé
Zika has been associated with a variety of severe neurologic manifestations including meningitis and encephalitis. We hypothesized that it may also cause mild to subclinical neurocognitive alterations during acute infection or over the long term. In this observational cohort study, we explored whether Zika cause subclinical or mild neurocognitive alterations, estimate its frequency and duration, and compare it to other acute illnesses in a cohort of people with suspected Zika infection, in the region of Tapachula in Chiapas, Mexico during 2016-2018. We enrolled patients who were at least 12 years old with suspected Zika virus infection and followed them up for 6 months. During each visit participants underwent a complete clinical exam, including a screening test for neurocognitive dysfunction (Montreal Cognitive Assessment score). We enrolled 406 patients [37 with Zika, 73 with dengue and 296 with other acute illnesses of unidentified origin (AIUO)]. We observed a mild and transient impact over cognitive functions in patients with Zika, dengue and with other AIUO. The probability of having an abnormal MoCA score (<26 points) was significantly higher in patients with Zika and AIUO than in those with dengue. Patients with Zika and AIUO had lower memory scores than patients with dengue (Zika vs. Dengue: -0.378, 95% CI-0.678 to -0.078;
Identifiants
pubmed: 33828518
doi: 10.3389/fneur.2021.631801
pmc: PMC8019918
doi:
Banques de données
ClinicalTrials.gov
['NCT02831699']
Types de publication
Journal Article
Langues
eng
Pagination
631801Subventions
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272200900001C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272200900031C
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Informations de copyright
Copyright © 2021 Belaunzarán-Zamudio, Ortega-Villa, Mimenza-Alvarado, Guerra-De-Blas, Aguilar-Navarro, Sepúlveda-Delgado, Hunsberger, Salgado, Ramos-Castañeda, Rincón León, Rodríguez de La Rosa, Nájera Cancino, Beigel, Caballero Sosa, Ruiz Hernández, Powers, Ruiz-Palacios and Lane.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Dement Neuropsychol. 2019 Jan-Mar;13(1):78-81
pubmed: 31073382
Stat Med. 2005 Feb 15;24(3):341-58
pubmed: 15547952
Int J Infect Dis. 2020 Sep;98:241-249
pubmed: 32593623
Am J Trop Med Hyg. 2007 Sep;77(3):521-4
pubmed: 17827371
Virol J. 2013 Feb 14;10:58
pubmed: 23410000
Front Cell Neurosci. 2019 Aug 27;13:389
pubmed: 31551711
Bull World Health Organ. 2010 Nov 1;88(11):815-23
pubmed: 21076562
PLoS Negl Trop Dis. 2018 Feb 12;12(2):e0006212
pubmed: 29432457
J Clin Microbiol. 2013 Jul;51(7):2172-81
pubmed: 23637298
Pharmaceuticals (Basel). 2019 Apr 17;12(2):
pubmed: 30999590
Rev Soc Bras Med Trop. 2018 May-Jun;51(3):347-351
pubmed: 29972566
PLoS Negl Trop Dis. 2019 Aug 26;13(8):e0007622
pubmed: 31449532
Open Forum Infect Dis. 2016 Oct 3;3(4):ofw203
pubmed: 28053996
Heart Lung. 2014 Sep-Oct;43(5):462-8
pubmed: 25035250
Cell Death Dis. 2016 Oct 27;7(10):e2440
pubmed: 27787521
PLoS Negl Trop Dis. 2019 Sep 17;13(9):e0007695
pubmed: 31527907
Curr Opin Immunol. 2019 Aug;59:1-8
pubmed: 30884384
PLoS Negl Trop Dis. 2021 Feb 16;15(2):e0009133
pubmed: 33591992
Rev Colomb Psiquiatr. 2018 Oct - Dec;47(4):237-243
pubmed: 30286846
Pediatr Neurol. 2018 Aug;85:16-20
pubmed: 30343688
J Clin Rheumatol. 2019 Dec;25(8):325-328
pubmed: 31764492
Neurology. 2019 May 21;92(21):e2406-e2420
pubmed: 31028126
Emerg Infect Dis. 2008 Aug;14(8):1232-9
pubmed: 18680646
Emerg Microbes Infect. 2018 Aug 22;7(1):148
pubmed: 30131486
Stroke. 2016 Oct;47(10):2482-7
pubmed: 27625375
Euro Surveill. 2016 Apr 21;21(16):
pubmed: 27123558
JAMA Neurol. 2017 Oct 1;74(10):1190-1198
pubmed: 28806453
Cell Host Microbe. 2008 Sep 11;4(3):229-38
pubmed: 18779049
Nat Neurosci. 2017 Aug 29;20(9):1191-1192
pubmed: 28849792
Front Cell Infect Microbiol. 2017 Oct 25;7:449
pubmed: 29119088
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
J Alzheimers Dis. 2017;58(3):695-699
pubmed: 28453481
Nat Commun. 2019 Sep 5;10(1):3890
pubmed: 31488835
Microbiol Spectr. 2014 Dec;2(6):
pubmed: 26104444
Neural Regen Res. 2012 Jul 15;7(20):1591-8
pubmed: 25657698