Accuracy and Incremental Yield of the Chest X-Ray in Screening for Tuberculosis in Uganda: A Cross-Sectional Study.
Journal
Tuberculosis research and treatment
ISSN: 2090-150X
Titre abrégé: Tuberc Res Treat
Pays: Egypt
ID NLM: 101576351
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
11
2020
revised:
02
03
2021
accepted:
08
03
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
9
4
2021
Statut:
epublish
Résumé
The WHO END TB strategy requires ≥90% case detection to combat tuberculosis (TB). Increased TB case detection requires a more sensitive and specific screening tool. Currently, the symptoms recommended for screening TB have been found to be suboptimal since up to 44% of individuals with TB are asymptomatic. The chest X-ray (CXR) as a screening tool for pulmonary TB was evaluated in this study, as well as its incremental yield in TB diagnosis using a cross-sectional study involving secondary analysis of data of 4512 consented/assented participants ≥15 years who participated in the Uganda National TB prevalence survey between 2014 and 2015. Participants with a cough ≥2 weeks, fever, weight loss, and night sweats screened positive for TB using the symptoms screening method, while participants with a TB defining abnormality on CXR screened positive for TB by the CXR screening method. The Löwenstein-Jensen (LJ) culture was used as a gold standard for TB diagnosis. The CXR had 93% sensitivity and 65% specificity compared to LJ culture results, while symptoms had 76% sensitivity and 31% specificity. The screening algorithm involving the CXR in addition to symptoms led to a 38% increment in the yield of diagnosed tuberculosis. The number needed to screen using the CXR and symptoms screening algorithm was 32 compared to 45 when the symptoms are used alone. Therefore, the CXR in combination with symptoms is a good TB screening tool and increases the yield of diagnosed TB.
Identifiants
pubmed: 33828862
doi: 10.1155/2021/6622809
pmc: PMC8004368
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6622809Subventions
Organisme : FIC NIH HHS
ID : D43 TW009607
Pays : United States
Informations de copyright
Copyright © 2021 Joanitah Nalunjogi et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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