Seizures, Edema, Thrombosis, and Hemorrhages: An Update Review on the Medical Management of Gliomas.
BTRE
DOACs
edema
epilepsy
glioma
hemorrhages
thrombosis
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
10
2020
accepted:
04
02
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
9
4
2021
Statut:
epublish
Résumé
Patients affected with gliomas develop a complex set of clinical manifestations that deeply impact on quality of life and overall survival. Brain tumor-related epilepsy is frequently the first manifestation of gliomas or may occur during the course of disease; the underlying mechanisms have not been fully explained and depend on both patient and tumor factors. Novel treatment options derive from the growing use of third-generation antiepileptic drugs. Vasogenic edema and elevated intracranial pressure cause a considerable burden of symptoms, especially in high-grade glioma, requiring an adequate use of corticosteroids. Patients with gliomas present with an elevated risk of tumor-associated venous thromboembolism whose prophylaxis and treatment are challenging, considering also the availability of new oral anticoagulant drugs. Moreover, intracerebral hemorrhages can complicate the course of the illness both due to tumor-specific characteristics, patient comorbidities, and side effects of antithrombotic and antitumoral therapies. This paper aims to review recent advances in these clinical issues, discussing the medical management of gliomas through an updated literature review.
Identifiants
pubmed: 33828976
doi: 10.3389/fonc.2021.617966
pmc: PMC8019972
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
617966Informations de copyright
Copyright © 2021 Zoccarato, Nardetto, Basile, Giometto, Zagonel and Lombardi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurooncol Pract. 2018 Nov;5(4):246-250
pubmed: 30402263
J Clin Oncol. 1994 Sep;12(9):1886-9
pubmed: 8083712
J Neurooncol. 2011 Aug;104(1):225-31
pubmed: 21104297
Epileptic Disord. 2012 Dec;14(4):388-97
pubmed: 23248037
J Neurol. 2009 Sep;256(9):1519-26
pubmed: 19434440
Ann Neurol. 1983 Mar;13(3):334-6
pubmed: 6303201
Epilepsy Behav Case Rep. 2018 Oct 09;10:114-117
pubmed: 30377587
Int J Neurosci. 2020 May 3;:1-6
pubmed: 32316814
J Clin Oncol. 2009 Oct 1;27(28):4733-40
pubmed: 19720927
J Formos Med Assoc. 1999 May;98(5):365-7
pubmed: 10420706
Neuro Oncol. 2007 Apr;9(2):89-95
pubmed: 17327573
J Neurol Neurosurg Psychiatry. 2015 Oct;86(10):1158-62
pubmed: 25511789
Neurocrit Care. 2016 Feb;24(1):6-46
pubmed: 26714677
Oncologist. 2009 Nov;14(11):1131-8
pubmed: 19897538
Seizure. 2019 Jul;69:283-289
pubmed: 31141785
J Clin Oncol. 2018 Jul 10;36(20):2017-2023
pubmed: 29746227
Curr Opin Oncol. 2010 Nov;22(6):611-20
pubmed: 20706121
Neuro Oncol. 2014 Dec;16(12):1645-51
pubmed: 24987133
J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):366-73
pubmed: 25055819
Int J Mol Sci. 2016 Jun 29;17(7):
pubmed: 27367682
Ann Oncol. 2011 Sep;22 Suppl 6:vi85-92
pubmed: 21908511
Blood. 2008 May 15;111(10):4902-7
pubmed: 18216292
Epilepsy Res. 2020 Oct;166:106430
pubmed: 32712511
J Neurooncol. 1992 Oct;14(2):119-25
pubmed: 1331348
Lancet Neurol. 2007 May;6(5):421-30
pubmed: 17434097
Curr Oncol. 2014 Jun;21(3):e493-503
pubmed: 24940109
Neurol Sci. 2006 Nov;27(5):345-51
pubmed: 17122945
J Neurosurg Sci. 2003 Dec;47(4):201-10; discussion 210
pubmed: 14978474
N Engl J Med. 1998 Jul 9;339(2):80-5
pubmed: 9654538
Eur J Cancer. 1997 Sep;33(10):1592-6
pubmed: 9389920
Expert Rev Neurother. 2017 Feb;17(2):193-202
pubmed: 27484737
Neurology. 2010 Feb 9;74(6):494-501
pubmed: 20142616
Thromb Haemost. 1993 Sep 1;70(3):393-6
pubmed: 8259536
J Clin Oncol. 2017 Jul 20;35(21):2439-2449
pubmed: 28640707
Pediatr Neurol. 2015 Sep;53(3):211-5
pubmed: 26302700
Lancet. 2005 Sep 17-23;366(9490):985-90
pubmed: 16168780
Eur J Neurol. 2017 Oct;24(10):1283-1289
pubmed: 28796376
Neurology. 2000 May 23;54(10):1886-93
pubmed: 10822423
Neurosurgery. 1982 Apr;10(4):437-44
pubmed: 7099393
J Neurosurg. 2008 Feb;108(2):227-35
pubmed: 18240916
Lancet Oncol. 2019 Jan;20(1):110-119
pubmed: 30522967
Brain Behav. 2018 Nov;8(11):e01067
pubmed: 30334378
Neurology. 2004 Jun 8;62(11):2025-30
pubmed: 15184609
Anticancer Res. 2018 Jul;38(7):4361-4366
pubmed: 29970574
Semin Thromb Hemost. 2019 Jun;45(4):334-341
pubmed: 31041803
Stroke. 2015 Jul;46(7):2032-60
pubmed: 26022637
Seizure. 2018 Feb;55:76-82
pubmed: 29414139
Cancer. 2004 Apr 15;100(8):1717-23
pubmed: 15073862
J Neurol Sci. 2017 Jan 15;372:413-416
pubmed: 27856004
Neuroscience. 2010 Jul 28;168(4):1036-46
pubmed: 19682555
Handb Clin Neurol. 2016;134:267-85
pubmed: 26948360
J Clin Oncol. 2020 Feb 10;38(5):496-520
pubmed: 31381464
J Thromb Haemost. 2010 Feb;8(2):221-7
pubmed: 19912518
Neuro Oncol. 2014 Apr;16(4):584-8
pubmed: 24311644
J Thromb Haemost. 2016 Sep;14(9):1736-40
pubmed: 27306689
Cancer. 1996 May 1;77(9):1877-83
pubmed: 8646688
Blood. 2017 Mar 30;129(13):1831-1839
pubmed: 28073783
Stroke. 1986 Jul-Aug;17(4):590-5
pubmed: 3526643
AJNR Am J Neuroradiol. 2015 May;36(5):886-92
pubmed: 25634719
Neuro Oncol. 2012 Sep;14 Suppl 4:iv73-80
pubmed: 23095833
Cancer Cell. 2007 Jan;11(1):83-95
pubmed: 17222792
Curr Atheroscler Rep. 2005 Jul;7(4):280-8
pubmed: 15975321
PLoS One. 2014 Jul 15;9(7):e102484
pubmed: 25025282
Curr Atheroscler Rep. 2012 Aug;14(4):314-21
pubmed: 22562528
Neuro Oncol. 2016 Feb;18(2):252-60
pubmed: 26289592
J Neurooncol. 2005 May;72(3):255-60
pubmed: 15937649
Front Neurol. 2020 Aug 19;11:813
pubmed: 32973649
Acta Neuropathol. 2016 Dec;132(6):917-930
pubmed: 27664011
J Neurooncol. 2019 May;142(3):463-470
pubmed: 30778733
Radiat Oncol. 2017 Aug 10;12(1):126
pubmed: 28797254
Medicine (Baltimore). 1985 Jan;64(1):16-35
pubmed: 3965856
Neurosurg Rev. 2019 Sep;42(3):603-618
pubmed: 30073426
J Neurooncol. 2016 Sep;129(3):461-469
pubmed: 27377653
Neurol Sci. 2019 Oct;40(10):2217-2234
pubmed: 31392641
Neuro Oncol. 2013 Dec;15(12):1739-49
pubmed: 23897633
J Neurosurg. 1998 Aug;89(2):200-5
pubmed: 9688113
Hematol Oncol Clin North Am. 2006 Dec;20(6):1337-61
pubmed: 17113467
Epilepsia. 2020 Apr;61(4):647-656
pubmed: 32329527
Neuro Oncol. 2018 Feb 19;20(3):324-331
pubmed: 29016869
Thromb Res. 2012 Apr;129 Suppl 1:S46-9
pubmed: 22682132
J Neurooncol. 2015 May;122(3):421-9
pubmed: 25670390
Curr Neurol Neurosci Rep. 2017 Sep;17(9):70
pubmed: 28755329
J Neurooncol. 2013 May;113(1):111-6
pubmed: 23462855
J Neurooncol. 2012 Feb;106(3):449-59
pubmed: 21971734
Neurosurgery. 2019 Aug 1;85(2):E332-E340
pubmed: 30395304
Thromb Res. 2009 Apr;123(6):837-44
pubmed: 18977517
Epilepsy Behav. 2017 Aug;73:83-89
pubmed: 28623754
Expert Rev Neurother. 2016 Sep;16(9):1087-92
pubmed: 27248204
J Exp Clin Cancer Res. 2017 Jun 6;36(1):76
pubmed: 28587680
PLoS One. 2019 Feb 4;14(2):e0211644
pubmed: 30716120
N Engl J Med. 2018 Feb 15;378(7):615-624
pubmed: 29231094
Neurosurgery. 2010 Dec;67(6):1799-815; discussion 1815
pubmed: 21107211
Curr Opin Neurol. 2010 Dec;23(6):592-6
pubmed: 20881488
J Neurooncol. 2016 May;127(3):445-53
pubmed: 26758059
Neuro Oncol. 2019 Feb 19;21(3):370-379
pubmed: 30312433
Oncol Lett. 2017 Jun;13(6):4093-4100
pubmed: 28599411
N Engl J Med. 2017 Nov 16;377(20):1954-1963
pubmed: 29141164
Neuro Oncol. 2013 Jul;15(7):961-7
pubmed: 23680820
Epilepsy Res. 2015 Jan;109:100-5
pubmed: 25524848
Chest. 2008 Jun;133(6 Suppl):454S-545S
pubmed: 18574272
Neurosurgery. 2012 Apr;70(4):921-8; discussion 928
pubmed: 21997540
Int J Neurosci. 2019 Jun;129(6):593-597
pubmed: 30507318
Curr Neurol Neurosci Rep. 2017 Jan;17(1):5
pubmed: 28138871
Support Care Cancer. 2002 May;10(4):322-8
pubmed: 12029432
J Neurooncol. 2012 Jan;106(2):353-66
pubmed: 21785913
AJNR Am J Neuroradiol. 1995 Apr;16(4):693-9
pubmed: 7611024
Arch Neurol. 2010 Mar;67(3):343-6
pubmed: 20212232
J Neurooncol. 2020 Jan;146(1):171-180
pubmed: 31834582
Front Neurol. 2020 Jun 25;11:592
pubmed: 32695064
Pharmacol Res. 2020 Jun;156:104786
pubmed: 32278037
Arch Intern Med. 2000 Aug 14-28;160(15):2327-32
pubmed: 10927730
Neurocrit Care. 2011 Dec;15(3):421-7
pubmed: 21547590
J Neurooncol. 2012 Feb;106(3):651-6
pubmed: 21847705
Epilepsy Behav. 2019 Dec;101(Pt B):106370
pubmed: 31300386
CNS Oncol. 2015;4(5):357-65
pubmed: 26509292
Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):504-9
pubmed: 23523186
Seizure. 2014 Aug;23(7):542-7
pubmed: 24810208
Epilepsy Behav. 2016 Dec;65:25-32
pubmed: 27863278
Neuro Oncol. 2016 Jun;18(6):779-89
pubmed: 26527735
Curr Opin Oncol. 2015 Nov;27(6):516-21
pubmed: 26447877
Brain Behav. 2020 Jun;10(6):e01612
pubmed: 32285623
Transl Res. 2020 Nov;225:33-53
pubmed: 32645431
J Clin Oncol. 2013 Jun 10;31(17):2189-204
pubmed: 23669224
Neurology. 2011 Sep 20;77(12):1156-64
pubmed: 21880994
Eur J Neurol. 2009 Jul;16(7):823-31
pubmed: 19473357
Curr Opin Oncol. 2019 Nov;31(6):548-553
pubmed: 31464760
J Clin Oncol. 2015 Feb 20;33(6):654-6
pubmed: 25605844
Neuro Oncol. 2015 Apr;17(4):488-504
pubmed: 25358508
J Physiol. 2006 Jun 1;573(Pt 2):413-25
pubmed: 16543270
Thromb Res. 2017 Aug;156:105-108
pubmed: 28624717
Neuro Oncol. 2016 Sep;18(9):1304-12
pubmed: 26951379
Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):986-992
pubmed: 26194676
J Neurooncol. 2015 Apr;122(2):263-71
pubmed: 25648357
J Neurol. 2011 Nov;258(11):2100-4
pubmed: 21674196
Epilepsia. 2013 Dec;54 Suppl 9:97-104
pubmed: 24328881
Thromb Res. 2012 Apr;129 Suppl 1:S22-9
pubmed: 22682129
Neuro Oncol. 2012 Apr;14(4):392-404
pubmed: 22307475
Neuro Oncol. 2012 Feb;14(2):230-41
pubmed: 22187341
Arch Neurol. 2010 Mar;67(3):336-42
pubmed: 20212231
Cochrane Database Syst Rev. 2018 May 23;5:CD007286
pubmed: 29791030
Sci Rep. 2015 Oct 01;5:14698
pubmed: 26423913
J Neurooncol. 2008 Jan;86(1):61-70
pubmed: 17598071
J Neurosurg Pediatr. 2017 Feb;19(2):249-253
pubmed: 27858578
J Neurosurg. 2013 Jun;118(6):1183-7
pubmed: 23451905
Neurology. 2006 Apr 25;66(8):1258-60
pubmed: 16636248
J Thromb Haemost. 2010 Sep;8(9):1959-65
pubmed: 20598077
Asian Pac J Cancer Prev. 2014;15(8):3425-8
pubmed: 24870733
Neurology. 2017 May 9;88(19):1805-1813
pubmed: 28404805
Neurology. 2017 Feb 21;88(8):789-796
pubmed: 28122904
Continuum (Minneap Minn). 2012 Apr;18(2):275-94
pubmed: 22810127
J Clin Oncol. 2016 Mar 1;34(7):731-9
pubmed: 26786929
Neuro Oncol. 2015 Jul;17(7):924-34
pubmed: 25813469
J Neurooncol. 2018 Jan;136(1):105-114
pubmed: 29030718
Oncologist. 2010;15(12):1329-34
pubmed: 21147867
Cancer Treat Res. 2019;179:179-189
pubmed: 31317488
J Neurosurg. 2007 Apr;106(4):601-8
pubmed: 17432710
Neurosurgery. 1998 Nov;43(5):1074-81
pubmed: 9802851
Lancet Oncol. 2017 Jun;18(6):e330-e340
pubmed: 28593859
Cancer. 2000 Aug 1;89(3):640-6
pubmed: 10931464
PLoS One. 2016 Jul 20;11(7):e0158206
pubmed: 27438472
Neuroscience. 2004;129(4):1011-20
pubmed: 15561416