Comparative Studies in the A30P and A53T α-Synuclein
C. elegans
Parkinson's disease
alpha-synuclein
drug discovery
neurodegenerative diseases
protein aggregation
protein misfolding
transgenic model
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
04
2020
accepted:
16
02
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
9
4
2021
Statut:
epublish
Résumé
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the disease. Patients carrying the A30P mutation typically exhibit a similar age of onset and symptoms as sporadic PD, while those carrying the A53T mutation generally have an earlier age of onset and an accelerated progression. We report two
Identifiants
pubmed: 33829010
doi: 10.3389/fcell.2021.552549
pmc: PMC8019828
doi:
Types de publication
Journal Article
Langues
eng
Pagination
552549Subventions
Organisme : Medical Research Council
ID : MR/K02292X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N012453/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203249/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S033947/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K015850/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0902243
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Perni, van der Goot, Limbocker, van Ham, Aprile, Xu, Flagmeier, Thijssen, Sormanni, Fusco, Chen, Challa, Kirkegaard, Laine, Ma, Müller, Sinnige, Kumita, Cohen, Seinstra, Kaminski Schierle, Kaminski, Barbut, De Simone, Knowles, Zasloff, Nollen, Vendruscolo and Dobson.
Déclaration de conflit d'intérêts
MZ and DB are inventors in a patent for the use of squalamine in the treatment of PD. CD, MV, SCo, and TK are co-founders, and MP is an employee of Wren Therapeutics, which is independently pursuing inhibitors of protein misfolding and aggregation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Obes Relat Metab Disord. 2001 May;25(5):689-97
pubmed: 11360152
Aging Cell. 2007 Aug;6(4):489-503
pubmed: 17608836
Genes Dev. 2005 Jul 1;19(13):1544-55
pubmed: 15998808
Nature. 2000 Mar 23;404(6776):394-8
pubmed: 10746727
Science. 1997 Jun 27;276(5321):2045-7
pubmed: 9197268
Nat Cell Biol. 2002 Feb;4(2):160-4
pubmed: 11813001
Commun Biol. 2020 Aug 13;3(1):435
pubmed: 32792544
Sci Adv. 2016 Feb 12;2(2):e1501244
pubmed: 26933687
Neurotoxicology. 2002 Oct;23(4-5):553-67
pubmed: 12428728
Neuron. 2013 Sep 18;79(6):1044-66
pubmed: 24050397
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10417-22
pubmed: 12122205
Science. 2003 Oct 31;302(5646):819-22
pubmed: 14593166
J Neurosci Methods. 2018 Aug 1;306:57-67
pubmed: 29452179
Trends Neurosci. 2016 Nov;39(11):750-762
pubmed: 27776749
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
Neuropathol Appl Neurobiol. 2008 Jun;34(3):255-71
pubmed: 18447897
J Vis Exp. 2018 Nov 28;(141):
pubmed: 30582580
Neurology. 2001 May 22;56(10):1355-62
pubmed: 11376188
ACS Chem Biol. 2018 Aug 17;13(8):2308-2319
pubmed: 29953201
ACS Chem Biol. 2019 Jul 19;14(7):1628-1636
pubmed: 31246415
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6469-73
pubmed: 9600990
Mov Disord. 2016 Feb;31(2):161-8
pubmed: 26347034
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9368-72
pubmed: 7568134
Annu Rev Cell Dev Biol. 2010;26:211-33
pubmed: 20500090
Sci Adv. 2017 Jun 21;3(6):e1700488
pubmed: 28691099
Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R183-94
pubmed: 17911161
PLoS Genet. 2008 Mar 21;4(3):e1000027
pubmed: 18369446
J Neuropathol Exp Neurol. 2003 Jun;62(6):644-54
pubmed: 12834109
J Mol Biol. 2002 Jan 25;315(4):799-807
pubmed: 11812148
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10328-33
pubmed: 27573854
Ann Neurol. 2004 Feb;55(2):164-73
pubmed: 14755719
Mov Disord. 2013 Jun;28(6):697-701
pubmed: 23674458
J Biol Chem. 2011 Oct 7;286(40):35104-18
pubmed: 21846727
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15978-83
pubmed: 21930925
Science. 2002 Dec 20;298(5602):2398-401
pubmed: 12471266
Mol Neurodegener. 2013 May 28;8:17
pubmed: 23714769
Science. 2003 Apr 25;300(5619):644-7
pubmed: 12690206
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
J Biol Chem. 1999 Apr 2;274(14):9843-6
pubmed: 10092675
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14912-7
pubmed: 22927396
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):571-6
pubmed: 10639120
J Biol Chem. 2006 Jan 6;281(1):334-40
pubmed: 16260788
Cell. 2010 Aug 20;142(4):601-12
pubmed: 20723760
PLoS One. 2014 Feb 14;9(2):e87133
pubmed: 24551051
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017
pubmed: 28096355
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7671-6
pubmed: 24817693
Nat Rev Mol Cell Biol. 2014 Jun;15(6):384-96
pubmed: 24854788
Chemphyschem. 2011 Feb 25;12(3):673-680
pubmed: 21308945
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1354-8
pubmed: 8433993
Front Neurosci. 2016 Jan 19;9:503
pubmed: 26834536
Trends Pharmacol Sci. 2014 Mar;35(3):127-35
pubmed: 24560688
Nat Rev Genet. 2002 May;3(5):356-69
pubmed: 11988761
Drug Discov Today Technol. 2013 Spring;10(1):e115-9
pubmed: 24050239
Curr Opin Neurobiol. 2016 Feb;36:15-22
pubmed: 26282834
Nat Commun. 2019 Jan 15;10(1):225
pubmed: 30644384
Neuron. 2006 Oct 5;52(1):33-8
pubmed: 17015225
Biochemistry. 2001 Sep 25;40(38):11604-13
pubmed: 11560511
Annu Rev Biochem. 2006;75:333-66
pubmed: 16756495
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6403-8
pubmed: 15084750
J Neurosci. 2006 Dec 13;26(50):13102-13
pubmed: 17167099
J Biol Chem. 2012 Mar 30;287(14):11526-32
pubmed: 22334684
Nat Chem Biol. 2015 Mar;11(3):229-34
pubmed: 25643172
Parkinsons Dis. 2010 Dec 20;2011:212706
pubmed: 21209707
PLoS Genet. 2009 Mar;5(3):e1000399
pubmed: 19266020
Nature. 2011 Apr 14;472(7342):226-9
pubmed: 21451522
Mol Neurobiol. 2013 Apr;47(2):552-60
pubmed: 22923346
J Nat Prod. 2000 May;63(5):631-5
pubmed: 10843574
Sci Rep. 2017 Nov 8;7(1):15045
pubmed: 29118344
Sci Rep. 2016 Jun 08;6:27125
pubmed: 27273030
J Am Geriatr Soc. 1998 Nov;46(11):1449-58
pubmed: 9809770
Biochim Biophys Acta. 2014 Sep;1842(9):1830-43
pubmed: 24973551
Science. 2017 Dec 15;358(6369):1440-1443
pubmed: 29242346
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208
pubmed: 28011763
J Biol Chem. 2002 Dec 13;277(50):49071-6
pubmed: 12377775
Nat Methods. 2008 Oct;5(10):865-7
pubmed: 18677319