nucleoside
oxygen-18
positron emission tomography (PET)
proton therapy
theranostic
Journal
International journal of particle therapy
ISSN: 2331-5180
Titre abrégé: Int J Part Ther
Pays: United States
ID NLM: 101674108
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
07
2020
accepted:
17
12
2020
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
9
4
2021
Statut:
epublish
Résumé
Proton therapy precisely delivers radiation to cancers to cause damaging strand breaks to cellular DNA, kill malignant cells, and stop tumor growth. Therapeutic protons also generate short-lived activated nuclei of carbon, oxygen, and nitrogen atoms in patients as a result of atomic transmutations that are imaged by positron emission tomography (PET). We hypothesized that the transition of Reported here is a feasibility study with a therapeutic proton beam used to irradiate H The These data support the idea of therapeutic transmutation in vitro as a biochemical consequence of proton activation of
Identifiants
pubmed: 33829069
doi: 10.14338/IJPT-D-20-00036.1
pii: THEIJPT-D-20-00036R2
pmc: PMC8019575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11-18Informations de copyright
©Copyright 2021 The Author(s).
Déclaration de conflit d'intérêts
Conflicts of Interest: Tyvin Rich, MD, Dongfeng Pan, PhD, and Mahendra Chordia, PhD, report inventorship/patents owned by the University of Virginia. Anatoly Dritschilo, MD, and Mira Jung, PhD, report industry/equity ownership in Shuttle Pharmaceuticals, Inc. David Beylin, MS, reports industry/equity ownership in BrainBIO, Inc. The authors have no additional conflicts of interest to disclose.
Références
J Biol Chem. 1973 Jun 10;248(11):3904-9
pubmed: 4736079
Nature. 1963 Feb 9;197:611-2
pubmed: 13978000
Chembiochem. 2004 May 3;5(5):637-43
pubmed: 15122635
PLoS One. 2012;7(7):e39685
pubmed: 22848359
Am J Nucl Med Mol Imaging. 2012;2(1):55-76
pubmed: 23133802
J Proteome Res. 2010 Sep 3;9(9):4779-89
pubmed: 20698492
J Cancer Res Clin Oncol. 1984;107(3):211-6
pubmed: 6736109
Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1163-7
pubmed: 8985039
Sci STKE. 2005 Jan 18;2005(267):pl2
pubmed: 15657263
J Nucl Med. 2013 Jun;54(6):903-12
pubmed: 23674576
Nucleic Acids Res. 1977 Jun;4(6):2075-81
pubmed: 896486
Nucleic Acids Res. 2013 Jul;41(12):e126
pubmed: 23632164
J Med Chem. 2015 Nov 12;58(21):8315-59
pubmed: 26200936
Sci Rep. 2018 Jan 18;8(1):1141
pubmed: 29348437
Theranostics. 2013 Sep 19;3(10):731-40
pubmed: 24312147
J Mol Biol. 1966 Aug;19(1):109-19
pubmed: 5338519
J Med Chem. 2020 Jun 25;63(12):6315-6386
pubmed: 32182061
J Labelled Comp Radiopharm. 2014 Jun 30;57(8):481-508
pubmed: 24996002
Radiat Res. 1987 Nov;112(2):331-40
pubmed: 3685260
Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1147-52
pubmed: 15001257
Brief Funct Genomic Proteomic. 2009 Mar;8(2):136-44
pubmed: 19151093
J Agric Food Chem. 2013 Aug 21;61(33):7904-8
pubmed: 23895305
Sci Rep. 2013;3:1770
pubmed: 23640660
Ann Saudi Med. 2011 Jan-Feb;31(1):3-13
pubmed: 21245592
Mol Cell Biochem. 1994 Nov 9;140(1):1-22
pubmed: 7877593
Biol Chem. 2019 Jun 26;400(7):847-865
pubmed: 30893050
Cancer Res. 1992 Feb 1;52(3):719-25
pubmed: 1732059
J Am Chem Soc. 1970 Feb 11;92(3):671-7
pubmed: 5411060
Anal Chem. 2013 Nov 19;85(22):11014-9
pubmed: 24131330
Chem Soc Rev. 2008 Feb;37(2):308-19
pubmed: 18197347
J Proteome Res. 2010 Jul 2;9(7):3741-9
pubmed: 20496949
Mass Spectrom Rev. 2018 Jan;37(1):57-80
pubmed: 27182900