Functional decline in the aphasic variant of Alzheimer's disease.


Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
10 2021
Historique:
revised: 29 01 2021
received: 24 09 2020
accepted: 18 02 2021
pubmed: 9 4 2021
medline: 30 12 2021
entrez: 8 4 2021
Statut: ppublish

Résumé

Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time. Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA Groups did not differ in demographics or aphasia severity at baseline, yet overall and subdomain scores of the ADLQ were significantly worse for PPA Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.

Identifiants

pubmed: 33829622
doi: 10.1002/alz.12331
pmc: PMC8499018
mid: NIHMS1680940
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1641-1648

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States

Informations de copyright

© 2021 the Alzheimer's Association.

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Auteurs

Stacey Moeller (S)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Jaiashre Sridhar (J)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Adam Martersteck (A)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Christina Coventry (C)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Alan Kuang (A)

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Hui Zhang (H)

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Sandra Weintraub (S)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

M-Marsel Mesulam (MM)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Emily Rogalski (E)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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