Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration.
biocompatibility
biointegration
biomaterials
healing
toxicology
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
26
02
2021
received:
07
12
2020
pubmed:
9
4
2021
medline:
23
6
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
The word "biocompatibility," is inconsistent with the observations of healing for so-called biocompatible biomaterials. The vast majority of the millions of medical implants in humans today, presumably "biocompatible," are walled off by a dense, avascular, crosslinked collagen capsule, hardly suggestive of life or compatibility. In contrast, one is now seeing examples of implant biomaterials that lead to a vascularized reconstruction of localized tissue, a biological reaction different from traditional biocompatible materials that generate a foreign body capsule. Both the encapsulated biomaterials and the reconstructive biomaterials qualify as "biocompatible" by present day measurements of biocompatibility. Yet, this new generation of materials would seem to heal "compatibly" with the living organism, where older biomaterials are isolated from the living organism by the dense capsule. This review/perspective article will explore this biocompatibility etymological conundrum by reviewing the history of the concepts around biocompatibility, today's standard methods for assessing biocompatibility, a contemporary view of the foreign body reaction and finally, a compendium of new biomaterials that heal without the foreign body capsule. A new definition of biocompatibility is offered here to address advances in biomaterials design leading to biomaterials that heal into the body in a facile manner.
Identifiants
pubmed: 33829678
doi: 10.1002/adhm.202002153
pmc: PMC8221530
mid: NIHMS1708626
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2002153Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE018701
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM128991
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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