Cutaneous Squamous Cell Carcinoma Development Is Associated with a Temporal Infiltration of ILC1 and NK Cells with Immune Dysfunctions.
Adoptive Transfer
Animals
Basic-Leucine Zipper Transcription Factors
/ physiology
Carcinoma, Squamous Cell
/ etiology
Humans
Immunity, Innate
Killer Cells, Natural
/ immunology
Lymphocytes
/ immunology
Mice
Natural Cytotoxicity Triggering Receptor 1
/ analysis
Neoplasm Staging
Skin Neoplasms
/ etiology
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
12
2020
revised:
24
02
2021
accepted:
07
03
2021
pubmed:
9
4
2021
medline:
15
12
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
NK cells and tissue-resident innate lymphoid cells (ILCs) are innate effectors found in the skin. To investigate their temporal dynamics and specific functions throughout the development of cutaneous squamous cell carcinoma (cSCC), we combined transcriptomic and immunophenotyping analyses in mouse and human cSCCs. We identified an infiltration of NK cells and ILC1s as well as the presence of a few ILC3s. Adoptive transfer of NK cells in NK cell‒ and ILC-deficient Nfil3
Identifiants
pubmed: 33831432
pii: S0022-202X(21)01135-0
doi: 10.1016/j.jid.2021.03.018
pii:
doi:
Substances chimiques
Basic-Leucine Zipper Transcription Factors
0
NCR1 protein, human
0
Natural Cytotoxicity Triggering Receptor 1
0
Nfil3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2369-2379Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.