Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.

Animals Chemoreceptor Cells / metabolism Epithelial Cells / metabolism Female Intestine, Small / cytology Male Mice Mice, Transgenic Receptors, G-Protein-Coupled / analysis
ADGRG2 Chemosensory cells GPCRs GPR64 Tuft cells

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
09 2021
Historique:
received: 17 02 2021
revised: 27 03 2021
accepted: 31 03 2021
pubmed: 9 4 2021
medline: 8 3 2022
entrez: 8 4 2021
Statut: ppublish

Résumé

GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation aimed to delineate the cellular expression of GPR64 throughout the body with focus on the gastrointestinal (GI) tract. Transgenic Gpr64 Expression of the Gpr64 GPR64 is expressed in chemosensory epithelial cells across a broad range of tissues; however, in the GI tract, GPR64 is remarkably selectively expressed in mature versus young immunoregulatory tuft cells.

Identifiants

DOI: 10.1016/j.molmet.2021.101231 PMID: 33831593 PMC: PMC8105302
pubmed: 33831593
pii: S2212-8778(21)00076-4
doi: 10.1016/j.molmet.2021.101231
pmc: PMC8105302
pii:
doi:

Substances chimiques

Adgrg2 protein, mouse 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101231

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.

Auteurs

Kaare V Grunddal (KV)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: grunddal@sund.ku.dk.

Sarah Tonack (S)

Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.

Kristoffer L Egerod (KL)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

Jonathan James Thompson (JJ)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

Natalia Petersen (N)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

Maja S Engelstoft (MS)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

Constance Vagne (C)

Department of Development and Stem Cells, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France; Université de Strasbourg, Illkirch, France.

Céline Keime (C)

Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France; Université de Strasbourg, Illkirch, France; Plateforme GenomEast, Infrastructure France Génomique, Illkirch, France.

Gérard Gradwohl (G)

Department of Development and Stem Cells, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France; Université de Strasbourg, Illkirch, France.

Stefan Offermanns (S)

Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.

Thue W Schwartz (TW)

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. Electronic address: tws@sund.ku.dk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules chimioréceptrices › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Adhesion receptor ADGRG2/GPR64 is in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Adhesion receptor ADGRG2/GPR64 is in the...