A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility.
Antioxidants
Male infertility
Oxidative stress
Reproduction, physicians
Survey
Journal
The world journal of men's health
ISSN: 2287-4208
Titre abrégé: World J Mens Health
Pays: Korea (South)
ID NLM: 101596899
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
27
02
2021
revised:
10
03
2021
accepted:
17
03
2021
pubmed:
9
4
2021
medline:
9
4
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
The use of antioxidants is common practice in the management of infertile patients. However, there are no established guidelines by professional societies on antioxidant use for male infertility. Using an online survey, this study aimed to evaluate the practice pattern of reproductive specialists to determine the clinical utility of oxidative stress (OS) testing and antioxidant prescriptions to treat male infertility. Responses from 1,327 participants representing 6 continents, showed the largest participant representation being from Asia (46.8%). The majority of participants were attending physicians (59.6%), with 61.3% having more than 10 years of experience in the field of male infertility. Approximately two-thirds of clinicians (65.7%) participated in this survey did not order any diagnostic tests for OS. Sperm DNA fragmentation was the most common infertility test beyond a semen analysis that was prescribed to study oxidative stress-related dysfunctions (53.4%). OS was mainly tested in the presence of lifestyle risk factors (24.6%) or sperm abnormalities (16.3%). Interestingly, antioxidants were prescribed by 85.6% of clinicians, for a duration of 3 (43.7%) or 3-6 months (38.6%). A large variety of antioxidants and dietary supplements were prescribed, and scientific evidence were mostly considered to be modest to support their clinical use. Results were not influenced by the physician's age, geographic origin, experience or training in male infertility. This study is the largest online survey performed to date on this topic and demonstrates 1) a worldwide understanding of the importance of this therapeutic option, and 2) a widely prevalent use of antioxidants to treat male infertility. Finally, the necessity of evidence-based clinical practice guidelines from professional societies is highlighted.
Identifiants
pubmed: 33831977
pii: 39.e17
doi: 10.5534/wjmh.210025
pmc: PMC8255391
doi:
Types de publication
Journal Article
Langues
eng
Pagination
470-488Informations de copyright
Copyright © 2021 Korean Society for Sexual Medicine and Andrology.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
Références
Genes (Basel). 2019 Mar 19;10(3):
pubmed: 30893955
Int J Reprod Biomed. 2016 Apr;14(4):231-40
pubmed: 27351024
Antioxidants (Basel). 2020 Mar 06;9(3):
pubmed: 32155908
Fertil Steril. 2014 Dec;102(6):1518-27
pubmed: 25458618
F1000Res. 2019 May 16;8:
pubmed: 31143441
Biomed Res Int. 2014;2014:426951
pubmed: 24800224
Transl Androl Urol. 2017 Sep;6(Suppl 4):S761-S764
pubmed: 29082208
Fertil Steril. 2020 Mar;113(3):552-560.e3
pubmed: 32111479
Andrologia. 2021 Feb;53(1):e13644
pubmed: 32427374
J Hum Reprod Sci. 2015 Oct-Dec;8(4):191-6
pubmed: 26752853
Reprod Biomed Online. 2007 Apr;14(4):418-21
pubmed: 17425820
Urology. 2020 Feb;136:133-141
pubmed: 31747549
Free Radic Biol Med. 2020 May 20;152:375-385
pubmed: 32165282
Clin J Sport Med. 2012 Mar;22(2):132-9
pubmed: 22246344
J Hum Reprod Sci. 2019 Jan-Mar;12(1):4-18
pubmed: 31007461
Arab J Urol. 2018 Jan 02;16(1):113-124
pubmed: 29713542
Cochrane Database Syst Rev. 2011 Jan 19;(1):CD007411
pubmed: 21249690
J Res Med Sci. 2013 Mar;18(3):184-7
pubmed: 23930112
J Urol. 2021 Jan;205(1):36-43
pubmed: 33295257
Cochrane Database Syst Rev. 2014;(12):CD007411
pubmed: 25504418
World J Mens Health. 2021 Apr;39(2):233-290
pubmed: 33474843
Indian J Urol. 2017 Jul-Sep;33(3):199-206
pubmed: 28717269
Neuroscience. 1999;93(1):313-20
pubmed: 10430495
Andrologia. 2017 Dec;49(10):
pubmed: 28124476
Ther Adv Urol. 2016 Oct;8(5):302-318
pubmed: 27695529
Andrologia. 2021 Mar;53(2):e13718
pubmed: 32628294
Antioxidants (Basel). 2019 Oct 01;8(10):
pubmed: 31581582
Arab J Urol. 2017 Dec 08;16(1):35-43
pubmed: 29713534
Andrologia. 2017 Jun;49(5):
pubmed: 27506165
Acta Inform Med. 2008;16(4):219-25
pubmed: 24109156
Antioxidants (Basel). 2019 Oct 16;8(10):
pubmed: 31623114
Health Technol Assess. 2001;5(31):1-256
pubmed: 11809125
World J Mens Health. 2019 Sep;37(3):296-312
pubmed: 31081299
Arch Ital Urol Androl. 2017 Oct 03;89(3):212-218
pubmed: 28969406
Reprod Biol Endocrinol. 2015 Apr 26;13:37
pubmed: 25928197
Fertil Steril. 2013 Mar 1;99(3):673-7
pubmed: 23391408
Hum Reprod. 2020 Oct 1;35(10):2188-2196
pubmed: 32976601
PLoS One. 2018 Jun 18;13(6):e0194239
pubmed: 29912881
Andrologia. 2019 Feb;51(1):e13162
pubmed: 30259539
Qual Health Res. 2020 Apr;30(5):783-792
pubmed: 31830860
Arch Androl. 2003 Mar-Apr;49(2):83-94
pubmed: 12623744
Lancet. 2021 Jan 23;397(10271):319-333
pubmed: 33308486
Cochrane Database Syst Rev. 2019 Mar 14;3:CD007411
pubmed: 30866036
J Gynecol Obstet Hum Reprod. 2018 Dec;47(10):565-572
pubmed: 30016715
Andrology. 2020 May;8(3):610-617
pubmed: 31828966
Andrology. 2016 Sep;4(5):816-24
pubmed: 27218783
World J Mens Health. 2020 Oct;38(4):412-471
pubmed: 32777871
JBRA Assist Reprod. 2021 Feb 02;25(1):76-80
pubmed: 32598834
Indian J Med Res. 2011 Sep;134:396-8
pubmed: 21985826
Int Braz J Urol. 2012 Sep-Oct;38(5):576-94
pubmed: 23131516
Reprod Biol Endocrinol. 2014 May 27;12:45
pubmed: 24884815
Fertil Steril. 2016 Sep 1;106(3):566-573.e10
pubmed: 27260688
Fertil Steril. 1995 Oct;64(4):825-31
pubmed: 7672157
Cad Saude Publica. 2015 Nov;31(11):2259-74
pubmed: 26840808
Transl Androl Urol. 2017 Sep;6(Suppl 4):S695-S696
pubmed: 29082952