Carnosine functionalized magnetic metal-organic framework nanocomposites for synergistic enrichment of phosphopeptides.
Enrichment
Metal organic framework
Phosphopeptides
Post-modification
Synergistic effect
Journal
Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534
Informations de publication
Date de publication:
01 May 2021
01 May 2021
Historique:
received:
22
12
2020
revised:
25
02
2021
accepted:
27
02
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Protein phosphorylation regulates the conformations and function of proteins, which plays an important part in organisms. However, systematic and in-depth analysis of phosphorylation often hinders on account of the low abundance and suppressed ionization of phosphopeptides. Various materials based on single enrichment mechanism show potential in phosphopeptides enrichment, but the enrichment performance is typically not satisfactory. Herein, we developed a carnosine (Car) functionalized magnetic metal organic framework designed as Fe
Identifiants
pubmed: 33832591
pii: S0003-2670(21)00209-9
doi: 10.1016/j.aca.2021.338383
pii:
doi:
Substances chimiques
Metal-Organic Frameworks
0
Phosphopeptides
0
Carnosine
8HO6PVN24W
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
338383Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.