Mechanism and dynamics of fatty acid photodecarboxylase.

Algal Proteins / chemistry Alkanes / metabolism Amino Acid Substitution Amino Acids / metabolism Bicarbonates / metabolism Biocatalysis Carbon Dioxide / metabolism Carboxy-Lyases / chemistry Catalytic Domain Chlorella / enzymology Crystallography, X-Ray Decarboxylation Electron Transport Fatty Acids / metabolism Flavin-Adenine Dinucleotide / chemistry Hydrogen Bonding Light Models, Molecular Mutant Proteins / chemistry Oxidation-Reduction Photons Protein Conformation Temperature

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
09 04 2021
Historique:
received: 29 06 2020
accepted: 17 02 2021
entrez: 9 4 2021
pubmed: 10 4 2021
medline: 28 4 2021
Statut: ppublish

Résumé

Fatty acid photodecarboxylase (FAP) is a photoenzyme with potential green chemistry applications. By combining static, time-resolved, and cryotrapping spectroscopy and crystallography as well as computation, we characterized

Identifiants

DOI: 10.1126/science.abd5687 PMID: 33833098
pubmed: 33833098
pii: 372/6538/eabd5687
doi: 10.1126/science.abd5687
pii:
doi:

Substances chimiques

Algal Proteins 0
Alkanes 0
Amino Acids 0
Bicarbonates 0
Fatty Acids 0
Mutant Proteins 0
Carbon Dioxide 142M471B3J
Flavin-Adenine Dinucleotide 146-14-5
Carboxy-Lyases EC 4.1.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

D Sorigué (D)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0003-1149-0757

K Hadjidemetriou (K)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.
ORCID: 0000-0003-1918-763X

S Blangy (S)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0001-5394-4695

G Gotthard (G)

European Synchrotron Radiation Facility, 38043 Grenoble, France.
ORCID: 0000-0003-2830-0286

A Bonvalet (A)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
ORCID: 0000-0001-6221-6307

N Coquelle (N)

Large-Scale Structures Group, Institut Laue Langevin, 38042 Grenoble Cedex 9, France.

P Samire (P)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
ORCID: 0000-0003-1555-6266

A Aleksandrov (A)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
ORCID: 0000-0002-8150-3931

L Antonucci (L)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
ORCID: 0000-0002-5995-5165

A Benachir (A)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.

S Boutet (S)

Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
ORCID: 0000-0003-3928-1244

M Byrdin (M)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.
ORCID: 0000-0002-6389-8714

M Cammarata (M)

Department of Physics, UMR UR1-CNRS 6251, University of Rennes 1, F-Rennes, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0003-3013-1186

S Carbajo (S)

Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
ORCID: 0000-0002-5292-4470

S Cuiné (S)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0002-3000-3355

R B Doak (RB)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

L Foucar (L)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

A Gorel (A)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
ORCID: 0000-0003-3376-670X

M Grünbein (M)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

E Hartmann (E)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

R Hienerwadel (R)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0002-8059-7956

M Hilpert (M)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
ORCID: 0000-0003-2304-2070

M Kloos (M)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.

T J Lane (TJ)

Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
ORCID: 0000-0003-2627-4432

B Légeret (B)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0002-0957-4700

P Legrand (P)

Synchrotron SOLEIL. L'Orme des Merisiers Saint-Aubin, BP 48, 91192 Gif-sur-Yvette, France.
ORCID: 0000-0003-2431-2255

Y Li-Beisson (Y)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0003-1064-1816

S L Y Moulin (SLY)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0002-7347-1247

D Nurizzo (D)

European Synchrotron Radiation Facility, 38043 Grenoble, France.
ORCID: 0000-0002-7367-5098

G Peltier (G)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.
ORCID: 0000-0002-2226-3931

G Schirò (G)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.

R L Shoeman (RL)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
ORCID: 0000-0002-1030-6738

M Sliwa (M)

Univ. Lille, CNRS, UMR 8516, LASIRE, LAboratoire de Spectroscopie pour les Interactions, la Réactivité et l'Environnement, 59000 Lille, France.

X Solinas (X)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
ORCID: 0000-0002-2459-4312

B Zhuang (B)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
ORCID: 0000-0002-9906-1190

T R M Barends (TRM)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
ORCID: 0000-0002-9488-3005

J-P Colletier (JP)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.
ORCID: 0000-0003-1819-4686

M Joffre (M)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
ORCID: 0000-0002-1408-8993

A Royant (A)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.
European Synchrotron Radiation Facility, 38043 Grenoble, France.
ORCID: 0000-0002-1919-8649

C Berthomieu (C)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0001-8784-5396

M Weik (M)

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0001-9297-642X

T Domratcheva (T)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
ORCID: 0000-0002-7001-1114

K Brettel (K)

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
ORCID: 0000-0001-6764-7042

M H Vos (MH)

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0003-0493-4831

I Schlichting (I)

Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0002-0936-7496

P Arnoux (P)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0003-4609-4893

P Müller (P)

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0002-3245-0810

F Beisson (F)

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. frederic.beisson@cea.fr pavel.muller@i2bc.paris-saclay.fr pascal.arnoux@cea.fr Ilme.schlichting@mpimf-heidelberg.mpg.de marten.vos@polytechnique.edu tatjana.domratcheva@mpimf-heidelberg.mpg.de martin.weik@ibs.fr catherine.berthomieu@cea.fr.
ORCID: 0000-0001-9995-7387

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'algue › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Carbonates › Hydrogénocarbonates › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Métabolisme › Biocatalyse › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Dioxyde de carbone › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-carbon lyases › Carboxy-lyases › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Chlorophyta › Chlorella › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Métabolisme › Décarboxylation › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Transport d'électrons › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Lipides › Acides gras › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Flavines › Riboflavine › Flavine adénine dinucléotide › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mutantes › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Photons › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Mechanism and dynamics of fatty acid...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Mechanism and dynamics of fatty acid...