Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 04 2021
08 04 2021
Historique:
received:
17
12
2020
accepted:
08
03
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
9
11
2021
Statut:
epublish
Résumé
When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming β-cell plasticity in later life is a poorly studied area. The imprinted Igf2 (insulin-like growth factor 2) gene is highly transcribed during early life and has been identified in recent genome-wide association studies as a type 2 diabetes susceptibility gene in humans. Hence, here we investigate the long-term phenotypic metabolic consequences of conditional Igf2 deletion in pancreatic β-cells (Igf2
Identifiants
pubmed: 33833312
doi: 10.1038/s41598-021-87292-x
pii: 10.1038/s41598-021-87292-x
pmc: PMC8032793
doi:
Substances chimiques
IGF2 protein, mouse
0
Insulin
0
Insulin-Like Growth Factor II
67763-97-7
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7717Subventions
Organisme : Medical Research Council
ID : MC_UU_12012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H003312/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC 979241
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC_MC_UU_12012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC_MC_UU_12012/5
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRC_MC_UU_00014/4
Pays : United Kingdom
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