Evidence for early dispersal of domestic sheep into Central Asia.


Journal

Nature human behaviour
ISSN: 2397-3374
Titre abrégé: Nat Hum Behav
Pays: England
ID NLM: 101697750

Informations de publication

Date de publication:
09 2021
Historique:
received: 07 09 2020
accepted: 17 02 2021
pubmed: 10 4 2021
medline: 7 10 2021
entrez: 9 4 2021
Statut: ppublish

Résumé

The development and dispersal of agropastoralism transformed the cultural and ecological landscapes of the Old World, but little is known about when or how this process first impacted Central Asia. Here, we present archaeological and biomolecular evidence from Obishir V in southern Kyrgyzstan, establishing the presence of domesticated sheep by ca. 6,000 BCE. Zooarchaeological and collagen peptide mass fingerprinting show exploitation of Ovis and Capra, while cementum analysis of intact teeth implicates possible pastoral slaughter during the fall season. Most significantly, ancient DNA reveals these directly dated specimens as the domestic O. aries, within the genetic diversity of domesticated sheep lineages. Together, these results provide the earliest evidence for the use of livestock in the mountains of the Ferghana Valley, predating previous evidence by 3,000 years and suggesting that domestic animal economies reached the mountains of interior Central Asia far earlier than previously recognized.

Identifiants

pubmed: 33833423
doi: 10.1038/s41562-021-01083-y
pii: 10.1038/s41562-021-01083-y
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Historical Article Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1169-1179

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Asouti, E. & Fuller, D. Q. A contextual approach to the emergence of agriculture in southwest Asia: reconstructing early Neolithic plant-food production. Curr. Anthropol. 54, 299–345 (2013).
doi: 10.1086/670679
Conolly, J. et al. Meta-analysis of zooarchaeological data from SW Asia and SE Europe provides insight into the origins and spread of animal husbandry. J. Archaeol. Sci. 38, 538–545 (2011).
doi: 10.1016/j.jas.2010.10.008
Larson, G. et al. Current perspectives and the future of domestication studies. Proc. Natl Acad. Sci. U. S. A. 111, 6139–6146 (2014).
pubmed: 24757054 pmcid: 4035915 doi: 10.1073/pnas.1323964111
Willcox, G. Measuring grain size and identifying Near Eastern cereal domestication: evidence from the Euphrates Valley. J. Archaeol. Sci. 31, 145–150 (2004).
doi: 10.1016/j.jas.2003.07.003
Willcox, G. & Stordeur, D. Large-scale cereal processing before domestication during the tenth millennium cal BC in northern Syria. Antiquity 86, 99–114 (2012).
doi: 10.1017/S0003598X00062487
Larson, G. & Fuller, D. Q. The evolution of animal domestication. Annu. Rev. Ecol. Evol. Syst. 45, 115–136 (2014).
doi: 10.1146/annurev-ecolsys-110512-135813
Bocquet‐Appel, J. Paleoanthropological traces of a Neolithic demographic transition. Curr. Anthropol. 43, 637–650 (2002).
doi: 10.1086/342429
Bellwood, P. First Farmers: the Origins of Agricultural Societies (Wiley, 2004).
Omrak, A. et al. Genomic evidence establishes Anatolia as the source of the European Neolithic gene pool. Curr. Biol. 26, 270–275 (2016).
pubmed: 26748850 doi: 10.1016/j.cub.2015.12.019
Olalde, I. et al. The genomic history of the Iberian Peninsula over the past 8000 years. Science 363, 1230–1234 (2019).
pubmed: 30872528 pmcid: 6436108 doi: 10.1126/science.aav4040
Brace, S. et al. Ancient genomes indicate population replacement in early Neolithic Britain. Nat. Ecol. Evol. 3, 765–771 (2019).
pubmed: 30988490 pmcid: 6520225 doi: 10.1038/s41559-019-0871-9
Zeder, M. A. & Hesse, B. The initial domestication of goats (Capra hircus) in the Zagros mountains 10,000 years ago. Science 287, 2254–2257 (2000).
pubmed: 10731145 doi: 10.1126/science.287.5461.2254
Daly, K. G. et al. Ancient goat genomes reveal mosaic domestication in the Fertile Crescent. Science 361, 85–88 (2018).
pubmed: 29976826 doi: 10.1126/science.aas9411
Alberto, F. J. et al. Convergent genomic signatures of domestication in sheep and goats. Nat. Commun. 9, 813 (2018).
pubmed: 29511174 pmcid: 5840369 doi: 10.1038/s41467-018-03206-y
Zeder, M. A. in Human Dispersal and Species Movement: from Prehistory to the Present (eds Petraglia, M.D., Crassard, R. & Boivin, N.) p. 261 (Cambridge Univ. Press, 2017).
Vigne, J.-D. Early domestication and farming: what should we know or do for a better understanding? Anthropozoologica 50, 123–151 (2015).
doi: 10.5252/az2015n2a5
Pereira, F. & Amorim, A. Encyclopedia of Life Sciences https://doi.org/10.1002/9780470015902.a0022864 (2010).
Hermes, T. R. et al. Mitochondrial DNA of domesticated sheep confirms pastoralist component of Afanasievo subsistence economy in the Altai Mountains (3300–2900 cal BC). Archaeol. Res. Asia 24, 100232 (2020).
doi: 10.1016/j.ara.2020.100232
Wilkin, S. et al. Dairy pastoralism sustained eastern Eurasian steppe populations for 5,000 years. Nat. Ecol. Evol. 4, 346–355 (2020).
pubmed: 32127685 pmcid: 7212056 doi: 10.1038/s41559-020-1120-y
Hermes, T. R. et al. Early integration of pastoralism and millet cultivation in Bronze Age Eurasia. Proc. Biol. Sci. 286, 20191273 (2019).
pubmed: 31480978 pmcid: 6743000
Taylor, W. et al. Early pastoral economies along the Ancient Silk Road: biomolecular evidence from the Alay Valley, Kyrgyzstan. PLoS ONE 13, e0205646 (2018).
pubmed: 30379865 pmcid: 6209189 doi: 10.1371/journal.pone.0205646
Spengler, R. N. & Willcox, G. Archaeobotanical results from Sarazm, Tajikistan, an early Bronze Age settlement on the edge: agriculture and exchange. Environ. Archaeol. 18, 211–221 (2013).
doi: 10.1179/1749631413Y.0000000008
Korobkova, G. F. Tools and Economy of the Neolithic Populations in Central Asia (Nauka, 1969).
Masson, V. M. The Jeitun Settlement: the Emergence of a Productive Economy (Nauka, 1971).
Itina, M.A. History of Steppe Tribes of Southern Aral Sea Region (2–1 Ka BP) (Nauka, 1977).
Lamberg-Karlovsky, C. C. The Bronze Age khanates of Central Asia. Antiquity 68, 398–405 (1994).
doi: 10.1017/S0003598X00046743
Brunet, F. Pour une nouvelle étude de la culture néolithique de Kel’teminar. Ouzbékistan. Paléorient 31, 87–105 (2005).
doi: 10.3406/paleo.2005.5127
Masson, V. M. The Bronze Age in Khorasan. Hist. Civiliz. Cent. Asia 1, 225 (1999).
Ranov, V. A. Hissar culture - Neolithic mountain regions of Central Asia. in Stone Age of Northern, Middle and Eastern Asia 27–28 (Nauka, 1985).
Yablonsky, L. T. Kelteminar craniology. Intra-group analysis. Sov. Ethnogr., Mosc., USSR Acad. Sci. 2, 127–140 (1985).
Vinogradov, A. V. Drevnie okhotniki i rybolovy Sredneaziatskogo Mezhdurechija (Former hunters and fishermen of Central Asian Mesopotamia) (Nauka (Science), 1981a).
Vinogradov, A. V. in Kul ‘tura i iskusstvo drevnego Khorezma (Culture and Art of Ancient Khoresam) (eds Itina, M. A., Raporort, J. A. et al.) pp. 88–98 (1981b).
Harris, D. R., Origins of Agriculture in Western Central Asia https://doi.org/10.9783/9781934536513 (Univ. of Pennsylvania, 2010).
Dolukhanov, P. M. The ecological prerequisites for early farming in southern Turkmenia. Sov. Anthropol. Archeol. 19, 359–385 (1981).
doi: 10.2753/AAE1061-1959190304359
Lisitsina, G. N. in The Bronze Age Civilization of Central Asia: Recent Soviet Discoveries (ed. Kohl, P. L.) pp. 350–358 (M. E. Sharpe, 1981).
Larkum, M. in Origins of Agriculture in Western Central Asia: An Environmental–Archaeological Study (ed. Harris, D.) pp. 142–149 (Univ. of Pennsylvania Museum of Archaeology and Anthropology, 2010).
Ranov, V. A. & Korobkova, G. F., Tutkaul – multilayered settlement site of the Gissar culture in southern Tajikistan. Sov. Archaeol. 133–147 (1971).
Islamov, U. I., Obishirian Culture (FAN, 1980).
Fedorchenko, A. Y. et al. Personal ornament production technology in the early Holocene complexes of western Central Asia: insights from Obishir-5. Archaeol., Ethnol. Anthropol. Eurasia 46, 3–15 (2018).
doi: 10.17746/1563-0110.2018.46.1.003-015
Szymczak, K. & Khudzhanazarov, M., Exploring the Neolithic of the Kyzyl-Kums. Ayakagytma “The Site” and other collections. Swiatowit Suppl. Ser. P: Prehistory and Middle Ages 11. Central Asia–Prehist. Stud (2006).
Buckley, M., Collins, M., Thomas-Oates, J. & Wilson, J. C. Species identification by analysis of bone collagen using matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 23, 3843–3854 (2009).
pubmed: 19899187 doi: 10.1002/rcm.4316
Kerven, C., Steimann, B., Ashley, L., Dear, C. & ur Rahim, I. Pastoralism and Farming in Central Asia’s Mountains: a Research Review (Univ. of Central Asia, 2011).
Lieberman, D. E. Life history variables preserved in dental cementum microstructure. Science 261, 1162–1164 (1993).
pubmed: 8356448 doi: 10.1126/science.8356448
Klevezal, G. A. Recording Structures of Mammals: Determination of Age and Reconstruction of Life History (A. A. Balkema, 1996).
Diekwisch, T. G. The developmental biology of cementum. Int. J. Dev. Biol. 45, 695–706 (2001).
pubmed: 11669371
Klevezal, G. & Kleinenberg, S. Age determination of mammals from annual layers in teeth and bones of mammals. Trans. from Russian by the Israel Program for Scientific Translations, Jerusalem (1969).
Grue, H. & Jensen, B., Review of the formation of incremental lines in tooth cementum of terrestrial mammals [age determination, game animal, variation, sex, reproductive cycle, climate, region, condition of the animal]. Dan. Rev. Game Biol. 11 (1979).
Stock, S. R. et al. Cementum structure in Beluga whale teeth. Acta Biomater. 48, 289–299 (2017).
pubmed: 27836805 doi: 10.1016/j.actbio.2016.11.015
Gordon, B. C. Of Men and Reindeer Herds in French Magdalenian Prehistory https://doi.org/10.30861/9780860545040 (BAR Publishing, 1988).
Pike-Tay, A. Red Deer Hunting in the Upper Paleolithic of South-West France: a Study in Seasonality (BAR Oxford, 1991).
Burke, A. & Castanet, J. Histological observations of cementum growth in horse teeth and their application to archaeology. J. Archaeol. Sci. 22, 479–493 (1995).
doi: 10.1006/jasc.1995.0047
Frachetti, M. D. Multiregional emergence of mobile pastoralism and nonuniform institutional complexity across Eurasia. Curr. Anthropol. 53, 2–38 (2012).
doi: 10.1086/663692
Stiner, M. C. et al. A forager–herder trade-off, from broad-spectrum hunting to sheep management at Aşıklı Höyük, Turkey. Proc. Natl Acad. Sci. U. S. A. 111, 8404–8409 (2014).
pubmed: 24778242 pmcid: 4060719 doi: 10.1073/pnas.1322723111
Demirci, S. et al. Mitochondrial DNA diversity of modern, ancient and wild sheep (Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep. PLoS ONE 8, e81952 (2013).
pubmed: 24349158 pmcid: 3859546 doi: 10.1371/journal.pone.0081952
Meadows, J. R. S., Hiendleder, S. & Kijas, J. W. Haplogroup relationships between domestic and wild sheep resolved using a mitogenome panel. Heredity 106, 700–706 (2011).
pubmed: 20940734 doi: 10.1038/hdy.2010.122
Cai, D. et al. Early history of Chinese domestic sheep indicated by ancient DNA analysis of Bronze Age individuals. J. Archaeol. Sci. 38, 896–902 (2011).
doi: 10.1016/j.jas.2010.11.019
Meadows, J. R. S., Cemal, I., Karaca, O., Gootwine, E. & Kijas, J. W. Five ovine mitochondrial lineages identified from sheep breeds of the Near East. Genetics 175, 1371–1379 (2007).
pubmed: 17194773 pmcid: 1840082 doi: 10.1534/genetics.106.068353
Bruford, M. W. & Townsend, S. J., in Documenting Domestication: New Genetic and Archaeological Paradigms (eds Zeder, M. A., Bradley, D. G. & Emshwiller, E. A.) pp 306–316 (Univ. of California Press, 2006).
Arbuckle, B. S. & Atici, L. Initial diversity in sheep and goat management in Neolithic south-western. Asia. Levant. 45, 219–235 (2013).
doi: 10.1179/0075891413Z.00000000026
Hesse, B. Slaughter patterns and domestication: the beginnings of pastoralism in western Iran. Man 17, 403–417 (1982).
doi: 10.2307/2801705
Fijn, N., Living with Herds: Human–Animal Coexistence in Mongolia (Cambridge Univ. Press, 2011).
Frachetti, M. D., Smith, C. E., Traub, C. M. & Williams, T. Nomadic ecology shaped the highland geography of Asia’s Silk Roads. Nature 543, 193 (2017).
pubmed: 28277506 doi: 10.1038/nature21696
Jerardino, A., Fort, J., Isern, N. & Rondelli, B. Cultural diffusion was the main driving mechanism of the Neolithic transition in Southern Africa. PLoS ONE 9, e113672 (2014).
pubmed: 25517968 pmcid: 4269434 doi: 10.1371/journal.pone.0113672
van Klinken, G. J. Bone collagen quality indicators for palaeodietary and radiocarbon measurements. J. Archaeol. Sci. 26, 687–695 (1999).
doi: 10.1006/jasc.1998.0385
Reimer, P. J. et al. The IntCal20 Northern Hemisphere radiocarbon age calibration curve (0–55 cal kBP). Radiocarbon 62, 725–757 (2020).
doi: 10.1017/RDC.2020.41
Ramsey, C. B. Bayesian analysis of radiocarbon dates. Radiocarbon 51, 337–360 (2009).
doi: 10.1017/S0033822200033865
Wintle, A. G. & Prószyńska, H. TL dating of loess in Germany and Poland. PACT 9, 547–554 (1983).
Fedorowicz, S. et al. Loess–paleosol sequence at Korshiv (Ukraine): chronology based on complementary and parallel dating (TL, OSL), and litho-pedosedimentary analyses. Quat. Int. 296, 117–130 (2013).
doi: 10.1016/j.quaint.2012.06.001
Frechen, M. Systematic thermoluminescence dating of two loess profiles from the Middle Rhine Area (FRG). Quat. Sci. Rev. 11, 93–101 (1992).
doi: 10.1016/0277-3791(92)90048-D
Behrensmeyer, A. K. Taphonomic and ecologic information from bone weathering. Paleobiology 4, 150–162 (1978).
doi: 10.1017/S0094837300005820
van Doorn, N. L., Hollund, H. & Collins, M. J. A novel and non-destructive approach for ZooMS analysis: ammonium bicarbonate buffer extraction. Archaeol. Anthropol. Sci. 3, 281 (2011).
doi: 10.1007/s12520-011-0067-y
Welker, F. et al. Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne. Proc. Natl Acad. Sci. U. S. A. 113, 11162–11167 (2016).
pubmed: 27638212 pmcid: 5056053 doi: 10.1073/pnas.1605834113
Rendu, W. Hunting behavior and Neanderthal adaptability in the Late Pleistocene site of Pech-de-l’Azé I. J. Archaeol. Sci. 37, 1798–1810 (2010).
doi: 10.1016/j.jas.2010.01.037
Stutz, A. J. Polarizing microscopy identification of chemical diagenesis in archaeological cementum. J. Archaeol. Sci. 29, 1327–1347 (2002).
doi: 10.1006/jasc.2001.0805
Geusa, G. et al. in Osteodental Biology of the People of Portus Romae (Necropolis of Isola Sacra, 2nd-3rd Cent. AD) (eds Bondioli, L. & Macchiarelli, R.) (Roma, 1999).
Lieberman, D. E., Deacon, T. W. & Meadow, R. H. Computer image enhancement and analysis of cementum increments as applied to teeth of Gazella gazella. J. Archaeol. Sci. 17, 519–533 (1990).
doi: 10.1016/0305-4403(90)90033-2
Gorgé, O. et al. Analysis of ancient DNA in microbial ecology. Methods Mol. Biol. 1399, 289–315 (2016).
pubmed: 26791510 doi: 10.1007/978-1-4939-3369-3_17
Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracil-DNA-glycosylase treatment for screening of ancient DNA. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20130624 (2015).
pubmed: 25487342 pmcid: 4275898 doi: 10.1098/rstb.2013.0624
Kircher, M., Sawyer, S. & Meyer, M. Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. Nucleic Acids Res. 40, e3 (2012).
pubmed: 22021376 doi: 10.1093/nar/gkr771
Ginolhac, A., Rasmussen, M., Gilbert, M. T. P., Willerslev, E. & Orlando, L. mapDamage: testing for damage patterns in ancient DNA sequences. Bioinformatics 27, 2153–2155 (2011).
pubmed: 21659319 doi: 10.1093/bioinformatics/btr347
Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows–Wheeler transform. Bioinformatics 26, 589–595 (2010).
pubmed: 20080505 pmcid: 2828108 doi: 10.1093/bioinformatics/btp698
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).
pubmed: 17701901 pmcid: 1950838 doi: 10.1086/519795
Li, X. et al. Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nat. Commun. 11, 2815 (2020).
pubmed: 32499537 pmcid: 7272655 doi: 10.1038/s41467-020-16485-1
Li, H. et al. The sequence alignment/map format and SAMtools. Bioinformatics 25, 2078–2079 (2009).
pubmed: 19505943 pmcid: 2723002 doi: 10.1093/bioinformatics/btp352
DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43, 491 (2011).
pubmed: 21478889 pmcid: 3083463 doi: 10.1038/ng.806
Mallick, S. et al. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature 538, 201–206 (2016).
pubmed: 27654912 pmcid: 5161557 doi: 10.1038/nature18964
Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 35, 1547–1549 (2018).
pubmed: 29722887 pmcid: 5967553 doi: 10.1093/molbev/msy096
Stecher, G., Tamura, K. & Kumar, S. Molecular evolutionary genetics analysis (MEGA) for macOS. Mol. Biol. Evol. 37, 1237–1239 (2020).
pubmed: 31904846 pmcid: 7086165 doi: 10.1093/molbev/msz312
Tamura, K. & Nei, M. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol. Biol. Evol. 10, 512–526 (1993).
pubmed: 8336541
Murphy, D. J. People, Plants and Genes: The Story of Crops and Humanity (Oxford Univ. Press, 2007).
Lv, F.-H. et al. Mitogenomic meta-analysis identifies two phases of migration in the history of eastern Eurasian sheep. Mol. Biol. Evol. 32, 2515–2533 (2015).
pubmed: 26085518 pmcid: 4576706 doi: 10.1093/molbev/msv139

Auteurs

William T T Taylor (WTT)

Museum of Natural History, University of Colorado-Boulder, Boulder, CO, USA. william.taylor@colorado.edu.
Department of Archaeology, Max Planck Institute for the Science of Human History, Jena, Germany. william.taylor@colorado.edu.

Mélanie Pruvost (M)

De la Préhistoire à l'Actuel: Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux, Pessac, France.

Cosimo Posth (C)

Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.
Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.

William Rendu (W)

De la Préhistoire à l'Actuel: Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux, Pessac, France.
ArchaeoZOOlogy in Siberia and Central Asia - ZooSCAn, CNRS - IAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia.

Maciej T Krajcarz (MT)

Institute of Geological Sciences, Polish Academy of Sciences, Warszawa, Poland.

Aida Abdykanova (A)

American University of Central Asia, Bishkek, Kyrgyzstan.

Greta Brancaleoni (G)

Institute of Geological Sciences, Polish Academy of Sciences, Warszawa, Poland.

Robert Spengler (R)

Department of Archaeology, Max Planck Institute for the Science of Human History, Jena, Germany.

Taylor Hermes (T)

Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.

Stéphanie Schiavinato (S)

Faculté de Médecine Purpan, Université Paul Sabatier, Toulouse, France.

Gregory Hodgins (G)

Accelerator Mass Spectrometry Laboratory, University of Arizona, Tucson, AZ, USA.

Raphaela Stahl (R)

Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.

Jina Min (J)

School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

Saltanat Alisher Kyzy (S)

Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Russia.
Novosibirsk State University, Novosibirsk, Russia.

Stanisław Fedorowicz (S)

Department of Geomorphology and Quaternary Geology, University of Gdańsk, Gdańsk, Poland.

Ludovic Orlando (L)

American University of Central Asia, Bishkek, Kyrgyzstan.

Katerina Douka (K)

Department of Archaeology, Max Planck Institute for the Science of Human History, Jena, Germany.

Andrey Krivoshapkin (A)

Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Russia.
Novosibirsk State University, Novosibirsk, Russia.

Choongwon Jeong (C)

School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

Christina Warinner (C)

Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.
Department of Anthropology, Harvard University, Cambridge, MA, USA.

Svetlana Shnaider (S)

ArchaeoZOOlogy in Siberia and Central Asia - ZooSCAn, CNRS - IAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia. sveta.shnayder@gmail.com.
Institute of Archaeology and Ethnography SB RAS, Novosibirsk, Russia. sveta.shnayder@gmail.com.

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