COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.
COVID-19
GPCR (G Protein Coupled Receptors)
famotidine (PubChem CID: 3325)
histamine (H2) receptor
hyperinflammation state
mast cell activating disorder
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
11
2020
accepted:
25
01
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
10
4
2021
Statut:
epublish
Résumé
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no approved pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We have investigated several plausible hypotheses for famotidine activity including antiviral and host-mediated mechanisms of action. We propose that the principal mechanism of action of famotidine for relieving COVID-19 symptoms involves on-target histamine receptor H
Identifiants
pubmed: 33833683
doi: 10.3389/fphar.2021.633680
pii: 633680
pmc: PMC8021898
doi:
Types de publication
Journal Article
Langues
eng
Pagination
633680Subventions
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021 Malone, Tisdall, Fremont-Smith, Liu, Huang, White, Miorin, Moreno, Alon, Delaforge, Hennecker, Wang, Pottel, Blair, Roy, Smith, Hall, Tomera, Shapiro, Mittermaier, Kruse, García-Sastre, Roth, Glasspool-Malone and Ricke.
Déclaration de conflit d'intérêts
RM, PT, and GS were employed by the companies RW Malone MD LLC, Medical School Companion LLC, and Pharmorx LLC, respectively. In all three cases, their contributions to the work described were voluntary and uncompensated. By joint agreement, no patent rights relating to these findings have been asserted by any of the authors. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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