The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder.

Brain-Derived Neurotrophic Factor / genetics Depressive Disorder, Major / drug therapy Glial Cell Line-Derived Neurotrophic Factor Humans Signal Transduction Vascular Endothelial Growth Factor A
Brain-derived neurotrophic factor Glial cell-derived neurotrophic factor Major depressive disorder Neuroplasticity Neurotrophins

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2021
Historique:
entrez: 9 4 2021
pubmed: 10 4 2021
medline: 13 4 2021
Statut: ppublish

Résumé

According to the neurotrophic hypothesis of major depressive disorder (MDD), impairment in growth factor signaling might be associated with the pathology of this illness. Current evidence demonstrates that impaired neuroplasticity induced by alterations of neurotrophic growth factors and related signaling pathways may be underlying to the pathophysiology of MDD. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophic factor involved in the neurobiology of MDD. Nevertheless, developing evidence has implicated other neurotrophic factors, including neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), glial cell-derived neurotrophic factor (GDNF), and fibroblast growth factor (FGF) in the MDD pathophysiology. Here, we summarize the current literature on the involvement of neurotrophic factors and related signaling pathways in the pathophysiology of MDD.

Identifiants

DOI: 10.1007/978-981-33-6044-0_14 PMID: 33834404
pubmed: 33834404
doi: 10.1007/978-981-33-6044-0_14
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0
Glial Cell Line-Derived Neurotrophic Factor 0
Vascular Endothelial Growth Factor A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

257-272

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Auteurs

Meysam Amidfar (M)

Tehran University of Medical Sciences, Tehran, Iran.

Gislaine Zilli Réus (GZ)

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, Santa Catarina, Brazil.

Airam Barbosa de Moura (AB)

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, Santa Catarina, Brazil.

João Quevedo (J)

UT Health Center of Excellence on Mood Disorders, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX, USA.
Translational Psychiatry Program, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX, USA.

Yong-Ku Kim (YK)

Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Ansan, Republic of Korea. yongku@korea.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › The Role of Neurotrophic Factors in...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › The Role of Neurotrophic Factors in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteurs neurotrophiques dérivés des cellules gliales › Facteur neurotrophique dérivé des cellules gliales › The Role of Neurotrophic Factors in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Neurotrophic Factors in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The Role of Neurotrophic Factors in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › The Role of Neurotrophic Factors in...