Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study.

Blood Coagulation Factors / genetics Cardiovascular Diseases / epidemiology Genetic Predisposition to Disease Genome-Wide Association Study / methods Humans Japan / epidemiology Mendelian Randomization Analysis / methods Polymorphism, Single Nucleotide Risk Factors
Mendelian randomization analysis cardiovascular disease coagulation stroke venous thromboembolism

Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
20 04 2021
Historique:
pubmed: 10 4 2021
medline: 27 10 2021
entrez: 9 4 2021
Statut: ppublish

Résumé

Background We conducted Mendelian randomization analyses investigating the linear associations of genetically proxied inhibition of different coagulation factors with risk of common cardiovascular diseases. Methods and Results Genetic instruments proxying coagulation factor inhibition were identified from genome-wide association studies for activated partial thromboplastin time and prothrombin time in BioBank Japan (up to 58 110 participants). Instruments were identified for 9 coagulation factors (fibrinogen alpha, beta, and gamma chain; and factors II, V, VII, X, XI, and XII). Age- and sex-adjusted estimates for associations of the instruments with the outcomes were derived from UK Biobank and the FinnGen, CARDIoGRAMplusC4D (Coronary Artery Disease Genome-wide Replication and Meta-analysis), and MEGASTROKE consortia with numbers of incident and prevalent cases of 820 to 60 810. Genetically proxied inhibition of fibrinogen alpha, beta, and gamma chain, factor II, and factor XI were associated with reduced risk of venous thromboembolism (

Identifiants

DOI: 10.1161/JAHA.120.019644 PMID: 33834859 PMC: PMC8174173
pubmed: 33834859
doi: 10.1161/JAHA.120.019644
pmc: PMC8174173
doi:

Substances chimiques

Blood Coagulation Factors 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e019644

Subventions

Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Department of Health
ID : CL‐2020‐16‐001
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/4/34215
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom

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Auteurs

Shuai Yuan (S)

Unit of Cardiovascular and Nutritional Epidemiology Institute of Environmental MedicineKarolinska Institutet Stockholm Sweden.

Stephen Burgess (S)

Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom.
MRC Biostatistics Unit University of Cambridge United Kingdom.

Mike Laffan (M)

Centre for Haematology Imperial College London United Kingdom.

Amy M Mason (AM)

British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge United Kingdom.
National Institute for Health Research Cambridge Biomedical Research CentreUniversity of Cambridge and Cambridge University Hospitals Cambridge United Kingdom.

Martin Dichgans (M)

Institute for Stroke and Dementia Research University HospitalLMU Munich Germany.
Munich Cluster for Systems Neurology (SyNergy) Munich Germany.
German Centre for Neurodegenerative Diseases (DZNE, Munich) Munich Germany.

Dipender Gill (D)

Department of Biostatistics and Epidemiology School of Public Health Imperial College London United Kingdom.
Clinical Pharmacology and Therapeutics Section Institute of Medical and Biomedical Education and Institute for Infection and Immunity St George's, University of London United Kingdom.
Clinical Pharmacology Group, Pharmacy and Medicines Directorate St George's University Hospitals NHS Foundation Trust London United Kingdom.
Centre for Pharmacology & Therapeutics Department of Medicine Hammersmith CampusImperial College London United Kingdom.
Novo Nordisk Research Centre Oxford Oxford United Kingdom.

Susanna C Larsson (SC)

Unit of Cardiovascular and Nutritional Epidemiology Institute of Environmental MedicineKarolinska Institutet Stockholm Sweden.
Unit of Medical Epidemiology Department of Surgical Sciences Uppsala University Uppsala Sweden.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Maladies cardiovasculaires › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetically Proxied Inhibition of Coagulation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Genetically Proxied Inhibition of Coagulation...