Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.

Animals Antiviral Agents / chemistry Benzene Derivatives / chemistry Binding Sites Cell Line Cell Survival / drug effects Chikungunya Fever / drug therapy Chikungunya virus / physiology Dihydroorotate Dehydrogenase Disease Models, Animal Female Half-Life Humans Male Mice Mice, Inbred C57BL Microsomes, Liver / metabolism Molecular Docking Simulation Oxidoreductases Acting on CH-CH Group Donors / antagonists & inhibitors Structure-Activity Relationship Virus Replication / drug effects

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 04 2021
Historique:
pubmed: 10 4 2021
medline: 16 6 2021
entrez: 9 4 2021
Statut: ppublish

Résumé

A benzo[6]annulene, 4-(

Identifiants

DOI: 10.1021/acs.jmedchem.0c02183 PMID: 33835811 PMC: PMC9774970
pubmed: 33835811
doi: 10.1021/acs.jmedchem.0c02183
pmc: PMC9774970
mid: NIHMS1848501
doi:

Substances chimiques

Antiviral Agents 0
Benzene Derivatives 0
Dihydroorotate Dehydrogenase 0
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4762-4786

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI109680
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States

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Auteurs

S Kaleem Ahmed (SK)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Nicole N Haese (NN)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Jaden T Cowan (JT)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Vibha Pathak (V)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Omar Moukha-Chafiq (O)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Valerie J Smith (VJ)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Kevin J Rodzinak (KJ)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Fahim Ahmad (F)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Sixue Zhang (S)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Kiley M Bonin (KM)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Aaron D Streblow (AD)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Cassilyn E Streblow (CE)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Craig N Kreklywich (CN)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Clayton Morrison (C)

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.

Sanjay Sarkar (S)

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.

Nathaniel Moorman (N)

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.

Wes Sander (W)

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.

Robbie Allen (R)

Oregon Translational Research and Development Institute, Portland, Oregon 97239, United States.

Victor DeFilippis (V)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Babu L Tekwani (BL)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Mousheng Wu (M)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Alec J Hirsch (AJ)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Jessica L Smith (JL)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Nichole A Tower (NA)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Lynn Rasmussen (L)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Robert Bostwick (R)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Joseph A Maddry (JA)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Subramaniam Ananthan (S)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.
ORCID: 0000-0002-4791-9116

John M Gerdes (JM)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Corinne E Augelli-Szafran (CE)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.
ORCID: 0000-0002-7676-6120

Mark J Suto (MJ)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.

Thomas E Morrison (TE)

Department of Immunology and Microbiology, University of Colorado School of Medicine, 12800 E. 19th Avenue, Aurora, Colorado 80045, United States.

Mark T Heise (MT)

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.

Daniel N Streblow (DN)

Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, United States.

Ashish K Pathak (AK)

Drug Discovery Division, Southern Research, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States.
ORCID: 0000-0003-0143-7979

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Togaviridae › Infections à alphavirus › Fièvre chikungunya › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Togaviridae › Alphavirus › Virus du chikungunya › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydroorotate dehydrogenase › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Phénomènes physiques › Temps › Période › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Targeting Chikungunya Virus Replication by...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Targeting Chikungunya Virus Replication by...