Sex differences in resting EEG power in Fragile X Syndrome.
EEG gamma power
EEG theta power
FMRP
Fragile X Syndrome
Relative EEG power
Sex differences
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
30
10
2020
revised:
10
02
2021
accepted:
24
03
2021
pubmed:
10
4
2021
medline:
6
7
2021
entrez:
9
4
2021
Statut:
ppublish
Résumé
Electrophysiological alterations may represent a neural substrate of impaired neurocognitive processes and other phenotypic features in Fragile X Syndrome (FXS). However, the role of biological sex in electroencephalography (EEG) patterns that differentiate FXS from typical development has not been determined. This limits use of EEG in both the search for biomarkers of impairment in FXS as well as application of those markers to enhance our understanding of underlying neural mechanisms to speed treatment discovery. We investigated topographical relative EEG power in participants at rest in a sample of males and females with FXS and in age- and sex-matched typically developing controls (TDC) using a cluster-based analysis. While alterations in theta and low beta power were similar across males and females in FXS, relative power varied by sex in the alpha, upper beta, gamma, and epsilon frequency bands. Follow up analyses showed that Individual Alpha Peak Frequency (IAPF), a continuous variable that may capture atypicalities across the theta and alpha ranges in neurodevelopmental disorders, also varied by sex. Finally, performance on an auditory filtering task correlated with theta power in males, but not females with FXS. The impact of biological sex on resting state EEG power differences in FXS is discussed as it relates to potential GABAergic and glutamatergic etiologies of neurocognitive deficits in FXS.
Identifiants
pubmed: 33836434
pii: S0022-3956(21)00209-0
doi: 10.1016/j.jpsychires.2021.03.057
pmc: PMC8192450
mid: NIHMS1691278
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-95Subventions
Organisme : NIMH NIH HHS
ID : K23 MH112936
Pays : United States
Organisme : NCBDD CDC HHS
ID : U01 DD001185
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD104461
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Electroencephalogr Clin Neurophysiol. 1988 Feb;69(2):91-9
pubmed: 2446839
Neuron. 2015 Aug 19;87(4):699-715
pubmed: 26291156
Brain Sci. 2019 Jan 12;9(1):
pubmed: 30642066
Autism Res. 2019 Dec;12(12):1758-1773
pubmed: 31419043
Biol Psychol. 1997 Jan 31;44(3):187-209
pubmed: 9043653
Neuron. 2013 Feb 20;77(4):696-711
pubmed: 23439122
Brain Sci. 2020 Sep 30;10(10):
pubmed: 33008014
J Neurodev Disord. 2017 Mar 14;9:11
pubmed: 28316753
J Neurodev Disord. 2017 Jun 12;9:14
pubmed: 28616097
Electroencephalogr Clin Neurophysiol. 1984 Jan;57(1):1-12
pubmed: 6198138
Neurobiol Dis. 2019 Apr;124:563-572
pubmed: 30639292
Electroencephalogr Clin Neurophysiol. 1980 Sep;49(5-6):626-35
pubmed: 6158442
Cell Cycle. 2015;14(16):2559
pubmed: 26102499
J Neurodev Disord. 2014;6(1):16
pubmed: 26491488
J Neurodev Disord. 2014;6(1):40
pubmed: 25400705
Transl Psychiatry. 2016 Apr 19;6:e787
pubmed: 27093069
Am J Ment Defic. 1985 Mar;89(5):485-91
pubmed: 3993694
Neurobiol Dis. 2020 May;138:104794
pubmed: 32036032
Biol Psychol. 2013 Feb;92(2):216-9
pubmed: 23182872
Eur J Neurosci. 2018 Mar;47(6):643-651
pubmed: 28700096
Neurobiol Dis. 2018 Jun;114:65-73
pubmed: 29486296
Front Cell Neurosci. 2014 Aug 25;8:245
pubmed: 25202236
J Neurodev Disord. 2013 Sep 16;5(1):24
pubmed: 24040879
PLoS One. 2014 Feb 11;9(2):e88451
pubmed: 24523898
Clin Neurophysiol. 2008 Jun;119(6):1271-80
pubmed: 18387340
Psychiatry Res. 2019 Aug;278:213-217
pubmed: 31226547
FASEB J. 2020 Mar;34(3):3501-3518
pubmed: 32039504
Trends Neurosci. 2004 Jul;27(7):370-7
pubmed: 15219735
Neurobiol Dis. 2018 Jul;115:39-48
pubmed: 29605426
J Neurophysiol. 2008 Nov;100(5):2615-26
pubmed: 18784272
Clin Neurophysiol. 2001 May;112(5):806-14
pubmed: 11336896
J Neurosci Methods. 2007 Aug 15;164(1):177-90
pubmed: 17517438
Neurobiol Aging. 2018 Nov;71:149-155
pubmed: 30144647
Front Integr Neurosci. 2019 Aug 21;13:45
pubmed: 31496945
Neuroscience. 2005;130(2):549-58
pubmed: 15664711
Dev Sci. 2011 Sep;14(5):935-43
pubmed: 21884309
Electroencephalogr Clin Neurophysiol. 1990 Jun;75(6):482-91
pubmed: 1693893
Int J Dev Neurosci. 2011 Apr;29(2):163-70
pubmed: 21134438
Neural Comput. 1999 Feb 15;11(2):417-41
pubmed: 9950738
J Autism Dev Disord. 2012 Jul;42(7):1377-92
pubmed: 21972117