Predicting the duration of supplemental home oxygen in prematurely-born infants at discharge from neonatal care.
Discharge from neonatal care
Home oxygen
Prematurity
Journal
Early human development
ISSN: 1872-6232
Titre abrégé: Early Hum Dev
Pays: Ireland
ID NLM: 7708381
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
02
2021
revised:
05
03
2021
accepted:
09
03
2021
pubmed:
10
4
2021
medline:
15
12
2021
entrez:
9
4
2021
Statut:
ppublish
Résumé
Discharge home of preterm infants on supplemental oxygen has significant healthcare, parental psychological and financial implications, but the potential ability of clinical parameters at discharge to predict the duration of home oxygen has not been previously examined. To use clinical and epidemiological parameters available at discharge to predict the duration of home oxygen therapy. Retrospective observational cohort study with a primary and a validation cohort. Seventy one infants born <32 completed weeks of gestational age, born between 1/1/2013-1/1/2020 at King's College Hospital NHS Foundation trust and discharged home on supplemental oxygen were studied. Duration of home oxygen therapy. In a primary cohort of 52 infants with a median (IQR) gestational age of 26.4 (25.0-28.1) weeks and birth weight of 0.81 (0.69-0.96) kg, the duration of home oxygen was four (3-7) months (range: 1-22 months). The postmenstrual age (adjusted p = 0.001) and oxygen flow at discharge (adjusted p = 0.046) were independently associated with the duration of home oxygen therapy. In a validation cohort of 19 infants, the correlation coefficient between the calculated and the observed duration of home oxygen was 0.62, p = 0.005 and the coefficient of determination was 0.38. Infants discharged home on higher oxygen flows and at a greater postmenstrual age require a longer duration of home oxygen therapy and these parameters can be used to predict the duration of home oxygen therapy.
Sections du résumé
BACKGROUND
Discharge home of preterm infants on supplemental oxygen has significant healthcare, parental psychological and financial implications, but the potential ability of clinical parameters at discharge to predict the duration of home oxygen has not been previously examined.
AIMS
To use clinical and epidemiological parameters available at discharge to predict the duration of home oxygen therapy.
STUDY DESIGN
Retrospective observational cohort study with a primary and a validation cohort.
SUBJECTS
Seventy one infants born <32 completed weeks of gestational age, born between 1/1/2013-1/1/2020 at King's College Hospital NHS Foundation trust and discharged home on supplemental oxygen were studied.
OUTCOME MEASURE
Duration of home oxygen therapy.
RESULTS
In a primary cohort of 52 infants with a median (IQR) gestational age of 26.4 (25.0-28.1) weeks and birth weight of 0.81 (0.69-0.96) kg, the duration of home oxygen was four (3-7) months (range: 1-22 months). The postmenstrual age (adjusted p = 0.001) and oxygen flow at discharge (adjusted p = 0.046) were independently associated with the duration of home oxygen therapy. In a validation cohort of 19 infants, the correlation coefficient between the calculated and the observed duration of home oxygen was 0.62, p = 0.005 and the coefficient of determination was 0.38.
CONCLUSIONS
Infants discharged home on higher oxygen flows and at a greater postmenstrual age require a longer duration of home oxygen therapy and these parameters can be used to predict the duration of home oxygen therapy.
Identifiants
pubmed: 33836487
pii: S0378-3782(21)00052-9
doi: 10.1016/j.earlhumdev.2021.105353
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
105353Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.