Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study.
Adverse events
Allogeneic hematopoietic cell transplantation
Related donors
Journal
Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
28
08
2020
revised:
05
01
2021
accepted:
11
01
2021
entrez:
10
4
2021
pubmed:
11
4
2021
medline:
3
7
2021
Statut:
ppublish
Résumé
The incidence and risk factors for severe adverse events (SAEs) in related donors (RD) of hematopoietic cell transplants is unknown. The Related Donor Safe study is a prospective observational cohort of 1680 RDs and represents an opportunity to examine characteristics of SAEs in RDs. In this cohort, we found that SAEs were reported in a total 12 (0.71%) RDs. Of these, 5 SAEs occurred in bone marrow donors (5/404, 1.24%), and 7 (7/1276, 0.55%) were in donors of peripheral blood stem cells. All of the SAEs were considered to be related (definite, probable, or possible) to the donation process. There were no donor fatalities. Of the 12 RDs who experienced an SAE, 10 were either overweight or obese. Five of the 12 RDs had predonation medical conditions that would have resulted in either possible or definite ineligibility for donation were they being assessed as unrelated donors. These SAE data will be useful in the counseling of prospective RDs before planned donation and may be helpful in identifying donors who should be considered medically unsuitable for donation.
Identifiants
pubmed: 33836890
pii: S2666-6367(21)00010-5
doi: 10.1016/j.jtct.2021.01.009
pmc: PMC8036235
mid: NIHMS1666301
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
352.e1-352.e5Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL085707
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States
Informations de copyright
Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
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