Early Moves: a protocol for a population-based prospective cohort study to establish general movements as an early biomarker of cognitive impairment in infants.
community child health
developmental neurology & neurodisability
paediatrics
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
entrez:
10
4
2021
pubmed:
11
4
2021
medline:
20
5
2021
Statut:
epublish
Résumé
The current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes for these children and support them to reach their full life potential. Early Moves aims to identify early biomarkers, including general movements (GMs), for babies at risk of cognitive impairment, allowing early intervention within critical developmental windows to enable these children to have the best possible start to life. Early Moves is a double-masked prospective cohort study that will recruit 3000 term and preterm babies from a secondary care setting. Early Moves will determine the diagnostic value of abnormal GMs (at writhing and fidgety age) for mild, moderate and severe cognitive delay at 2 years measured by the Bayley-4. Parents will use the Baby Moves smartphone application to video their babies' GMs. Trained GMs assessors will be masked to any risk factors and assessors of the primary outcome will be masked to the GMs result. Automated scoring of GMs will be developed through applying machine-based learning to the data and the predictive value for an abnormal GM will be investigated. Screening algorithms for identification of children at risk of cognitive impairment, using the GM assessment (GMA), and routinely collected social and environmental profile data will be developed to allow more accurate prediction of cognitive outcome at 2 years. A cost evaluation for GMA implementation in preparation for national implementation will be undertaken including exploring the relationship between cognitive status and healthcare utilisation, medical costs, health-related quality of life and caregiver burden. Ethics approval has been granted by the Medical Research Ethics Committee of Joondalup Health Services and the Health Service Human Research Ethics Committee (1902) of Curtin University (HRE2019-0739). ACTRN12619001422112.
Identifiants
pubmed: 33837094
pii: bmjopen-2020-041695
doi: 10.1136/bmjopen-2020-041695
pmc: PMC8043010
doi:
Substances chimiques
Biomarkers
0
Banques de données
ANZCTR
['ACTRN12619001422112']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e041695Investigateurs
Jane Valentine
(J)
Alison Salt
(A)
Desiree Silva
(D)
Caroline Alexander
(C)
Natasha Amery
(N)
Arlette Coenen
(A)
Rose Morie
(R)
Jennifer Moore
(J)
Madeleine OConnor
(M)
Ravisha Srinivasjois
(R)
Jason Tan
(J)
Brad Jongeling
(B)
Elayne Downie
(E)
Ruth Last
(R)
Mary Sharp
(M)
John Wray
(J)
Sue-Anne Davidson
(SA)
Ashleigh Thornton
(A)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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