Paradigm shifts in electrophysiological mechanisms of atrial fibrillation.


Journal

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
ISSN: 1532-2092
Titre abrégé: Europace
Pays: England
ID NLM: 100883649

Informations de publication

Date de publication:
10 04 2021
Historique:
received: 09 10 2020
accepted: 03 12 2020
entrez: 10 4 2021
pubmed: 11 4 2021
medline: 10 8 2021
Statut: ppublish

Résumé

Determining the sequence of activation is a major source of information for understanding the electrophysiological mechanism(s) of atrial fibrillation (AF). However, the complex morphology of the electrograms hampers their analysis, and has stimulated generations of electrophysiologists to develop a large variety of technologies for recording, pre-processing, and analysis of fibrillation electrograms. This variability of approaches is mirrored by a large variability in the interpretation of fibrillation electrograms and, thereby, opinions regarding the basic electrophysiological mechanism(s) of AF vary widely. Multiple wavelets, different types of re-entry including rotors, double layers, multiple focal activation patterns all have been advocated, and a comprehensive and commonly accepted paradigm for the fundamental mechanisms of AF is still lacking. Here, we summarize the Maastricht perspective and Cleveland perspective regarding AF mechanism(s). We also describe some of the key observations in mapping of AF reported over the past decades, and how they changed over the years, often as results of new techniques introduced in the experimental field of AF research.

Identifiants

pubmed: 33837750
pii: 6047258
doi: 10.1093/europace/euaa384
pmc: PMC8035704
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

ii9-ii13

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL146463
Pays : United States

Informations de copyright

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.

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Auteurs

Ulrich Schotten (U)

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 6229 ER, Maastricht, The Netherlands.

Seungyup Lee (S)

Department of Medicine, Cardiovascular Research Institute, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Stef Zeemering (S)

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Universiteitssingel 50 6229 ER, Maastricht, The Netherlands.

Albert L Waldo (AL)

Department of Medicine, Cardiovascular Research Institute, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

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