The long-term genetic stability and individual specificity of the human gut microbiome.
Adult
Aged
Aged, 80 and over
Bacteria
/ classification
Bacterial Proteins
/ genetics
Drug Resistance, Microbial
Feces
/ microbiology
Female
Gastrointestinal Microbiome
Genomic Instability
Humans
Longitudinal Studies
Male
Metabolome
Metagenome
Microbiota
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Virulence Factors
/ genetics
Young Adult
bacterial genetics
complex traits
host fingerprint
human gut microbiome
human metabolism
individual specificity
longitudinal study
metagenomics
population-based cohort study
temporal stability
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
29 04 2021
29 04 2021
Historique:
received:
09
07
2020
revised:
02
12
2020
accepted:
11
03
2021
pubmed:
11
4
2021
medline:
21
10
2021
entrez:
10
4
2021
Statut:
ppublish
Résumé
By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183 metabolites in 338 individuals after 4 years, we characterize microbial stability and variation in relation to host physiology. Using these individual-specific and temporally stable microbial profiles, including bacterial SNPs and structural variations, we develop a microbial fingerprinting method that shows up to 85% accuracy in classifying metagenomic samples taken 4 years apart. Application of our fingerprinting method to the independent HMP cohort results in 95% accuracy for samples taken 1 year apart. We further observe temporal changes in the abundance of multiple bacterial species, metabolic pathways, and structural variation, as well as strain replacement. We report 190 longitudinal microbial associations with host phenotypes and 519 associations with plasma metabolites. These associations are enriched for cardiometabolic traits, vitamin B, and uremic toxins. Finally, mediation analysis suggests that the gut microbiome may influence cardiometabolic health through its metabolites.
Identifiants
pubmed: 33838112
pii: S0092-8674(21)00352-4
doi: 10.1016/j.cell.2021.03.024
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2302-2315.e12Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.