Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality.
COVID-19
Genetics
Interferon
SARS-Cov-2
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
08
12
2020
revised:
08
03
2021
accepted:
04
04
2021
pubmed:
11
4
2021
medline:
15
7
2021
entrez:
10
4
2021
Statut:
ppublish
Résumé
Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01-2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16-4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response.
Identifiants
pubmed: 33838280
pii: S0888-7543(21)00128-2
doi: 10.1016/j.ygeno.2021.04.002
pmc: PMC8025598
pii:
doi:
Substances chimiques
IFITM3 protein, human
0
Membrane Proteins
0
RNA-Binding Proteins
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1733-1741Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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