Evaluation of the in vivo fate of ultrapure alginate in a BALB/c mouse model.

Alginates / metabolism Animals Flow Cytometry / methods Liver / metabolism Macrophages / metabolism Mice Mice, Inbred BALB C Optical Imaging / methods Positron-Emission Tomography / methods Seaweed / chemistry Spleen / metabolism Tissue Distribution
Biodistribution Biomaterials MTS assay MacGreen mouse PET and fluorescent imaging Ultrapure alginate

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
15 Jun 2021
Historique:
received: 17 11 2020
revised: 17 02 2021
accepted: 13 03 2021
entrez: 11 4 2021
pubmed: 12 4 2021
medline: 25 8 2021
Statut: ppublish

Résumé

The linear anionic polysaccharide alginate (ALG) has been comprehensively studied for biomedical applications, yet thus far the in vivo fate of this polymer has not been explored in detail. The current study therefore evaluates the biodistribution of ultrapure ALG (M/G ratio ≥ 0.67 with a measured M

Identifiants

DOI: 10.1016/j.carbpol.2021.117947 PMID: 33838824
pubmed: 33838824
pii: S0144-8617(21)00334-9
doi: 10.1016/j.carbpol.2021.117947
pii:
doi:

Substances chimiques

Alginates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117947

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Anitha A (A)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Nicholas L Fletcher (NL)

Centre for Advanced Imaging (CAI), The University of Queensland, Brisbane, QLD, 4072, Australia; Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia; ARC Centre of Excellence for Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, QLD, 4072, Australia.

Zachary H Houston (ZH)

Centre for Advanced Imaging (CAI), The University of Queensland, Brisbane, QLD, 4072, Australia; Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia; ARC Centre of Excellence for Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, QLD, 4072, Australia.

Kristofer J Thurecht (KJ)

Centre for Advanced Imaging (CAI), The University of Queensland, Brisbane, QLD, 4072, Australia; Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia; ARC Centre of Excellence for Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, QLD, 4072, Australia.

Lisbeth Grøndahl (L)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia; Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia. Electronic address: l.grondahl@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Alginates › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Eucaryotes › Animaux › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Système digestif › Foie › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Stades d'organismes › Algue marine › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Evaluation of the in vivo fate of ultrapure...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Evaluation of the in vivo fate of ultrapure...