Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation.

Brain / diagnostic imaging Humans Immunity Inflammation / immunology Male Neuroimaging Positron-Emission Tomography Receptors, GABA / metabolism
Cerebral immunotolerance Innate immunity Lipopolysaccharide Neuroinflammation TSPO neuroimaging

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
07 2021
Historique:
received: 17 12 2020
revised: 17 03 2021
accepted: 07 04 2021
pubmed: 12 4 2021
medline: 24 6 2021
entrez: 11 4 2021
Statut: ppublish

Résumé

Despite increasing evidence that immune training within the brain may affect the clinical course of neuropsychiatric diseases, data on cerebral immune tolerance are scarce. This study in healthy volunteers examined the trajectory of the immune response systemically and within the brain following repeated lipopolysaccharide (LPS) challenges. Five young males underwent experimental human endotoxemia (intravenous administration of 2 ng/kg LPS) twice with a 7-day interval. The systemic immune response was assessed by measuring plasma cytokine levels. Four positron emission tomography (PET) examinations, using the translocator protein (TSPO) ligand

Identifiants

DOI: 10.1016/j.bbi.2021.04.004 PMID: 33839233
pubmed: 33839233
pii: S0889-1591(21)00161-6
doi: 10.1016/j.bbi.2021.04.004
pii:
doi:

Substances chimiques

Receptors, GABA 0
TSPO protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

321-329

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Annemieke M Peters van Ton (AM)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands.

Guus P Leijte (GP)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands.

Gerben M Franssen (GM)

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Medical Imaging, Nijmegen, the Netherlands.

Niklas Bruse (N)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands.

Jan Booij (J)

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Medical Imaging, Nijmegen, the Netherlands; Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Department of Radiology & Nuclear Medicine, Amsterdam, the Netherlands.

Janine Doorduin (J)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, the Netherlands.

Mark Rijpkema (M)

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Medical Imaging, Nijmegen, the Netherlands.

Matthijs Kox (M)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands.

Wilson F Abdo (WF)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands. Electronic address: f.abdo@radboudumc.nl.

Peter Pickkers (P)

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Human in vivo neuroimaging to detect...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human in vivo neuroimaging to detect...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Human in vivo neuroimaging to detect...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Human in vivo neuroimaging to detect...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Human in vivo neuroimaging to detect...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Human in vivo neuroimaging to detect...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Human in vivo neuroimaging to detect...