Butyrolactone and sesquiterpene derivatives as inhibitors of iNOS from the roots of Lindera glauca.
Animals
Dose-Response Relationship, Drug
Enzyme Inhibitors
/ chemistry
Lindera
/ chemistry
Lipopolysaccharides
/ antagonists & inhibitors
Mice
Molecular Structure
Nitric Oxide
/ antagonists & inhibitors
Nitric Oxide Synthase Type II
/ antagonists & inhibitors
Plant Roots
/ chemistry
RAW 264.7 Cells
Sesquiterpenes
/ chemistry
Structure-Activity Relationship
Anti-inflammatory activity
Butyrolactone
Lindera glauca
Sesquiterpene
iNOS inhibitor
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
23
02
2021
revised:
23
03
2021
accepted:
24
03
2021
pubmed:
12
4
2021
medline:
15
10
2021
entrez:
11
4
2021
Statut:
ppublish
Résumé
Nine previously undescribed butyrolactone and sesquiterpene derivatives, named cyclopentanone A (1), subamolides F and G (2 and 3), secosubamolide F (4), rupestonic acids J - L (5-7), linderaguaianols A and B (8 and 9), together with six known ones 10-15 were isolated from the roots of Lindera glauca. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and Mo
Identifiants
pubmed: 33839581
pii: S0045-2068(21)00248-0
doi: 10.1016/j.bioorg.2021.104871
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Lipopolysaccharides
0
Sesquiterpenes
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type II
EC 1.14.13.39
Nos2 protein, mouse
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104871Informations de copyright
Copyright © 2021. Published by Elsevier Inc.