Crossed cerebellar diaschisis: risk factors and prognostic value in focal cortical dysplasia by
18F-FDG PET
Crossed cerebellar diaschisis
Focal cortical dysplasia
Medically intractable epilepsy
Journal
Annals of nuclear medicine
ISSN: 1864-6433
Titre abrégé: Ann Nucl Med
Pays: Japan
ID NLM: 8913398
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
03
12
2020
accepted:
26
03
2021
pubmed:
12
4
2021
medline:
19
11
2021
entrez:
11
4
2021
Statut:
ppublish
Résumé
Crossed cerebellar diaschisis (CCD) has been widely studied in hemispheric stroke but is less characterized in epilepsy. In this study, we used One hundred medically intractable epilepsy patients pathologically diagnosed with FCD postoperatively were included and classified into two groups: CCD+ and CCD-. PET/CT images were analyzed qualitatively by visual assessment and semi-quantitatively using the absolute asymmetry index (|AI|). Clinical factors, including age, sex, body mass index (BMI), age at seizure onset, epilepsy duration, seizure type, seizure frequency, electroencephalography (EEG) and brain magnetic resonance imaging (MRI), were retrospectively assessed from medical records. Follow-up outcomes were evaluated according to the Engel classification at 3, 6, 12, 24 and 36 months postoperatively. Of the 100 patients, 77 (77.0%) were classified as CCD-, and 23 (23.0%) were classified as CCD + . CCD+ patients had a higher number of lobes involved on PET (3.61 ± 2.16 vs 2.26 ± 1.01, P < 0.001) than CCD- patients. CCD- patients showed more negative MRI results than CCD + patients (P = 0.02). At 12 months postoperatively, 70.7% (29/41) of CCD- patients and 30.8% (4/13) of CCD + patients presented a favourable prognosis (P = 0.02). Significant differences in the average |AI| values in the posterior frontal and anterior temporal lobes were found between CCD+ and CCD- patients (P < 0.05). The number of lobes involved on PET, structural anomalies on MRI, the |AI| values in the posterior frontal and anterior temporal lobes may be predisposing factors for CCD. CCD occurrence may help predict the prognosis of FCD patients at 12 months postoperatively.
Identifiants
pubmed: 33840039
doi: 10.1007/s12149-021-01613-8
pii: 10.1007/s12149-021-01613-8
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-727Subventions
Organisme : The National Key Research and Development Program of China
ID : 2016YFC0103909
Organisme : Project supported by the National Natural Science Foundation of China
ID : 81671662
Organisme : Beijing Municipal Administration of Hospitals' Ascent Plan
ID : DFL20180802
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