Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla.

depression glutamate glutamine ketamine ketamine metabolites magnetic resonance spectroscopy neurotransmitters posterior cingulate cortex

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2021
Historique:
received: 24 09 2020
accepted: 23 02 2021
entrez: 12 4 2021
pubmed: 13 4 2021
medline: 13 4 2021
Statut: epublish

Résumé

Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine's immediate psychomimetic side-effects were linked to glutamate changes, proton MRS (

Identifiants

pubmed: 33841073
doi: 10.3389/fnins.2021.609485
pmc: PMC8024494
doi:

Types de publication

Journal Article

Langues

eng

Pagination

609485

Informations de copyright

Copyright © 2021 Bednarik, Spurny, Silberbauer, Svatkova, Handschuh, Reiter, Konadu, Stimpfl, Spies, Bogner and Lanzenberger.

Déclaration de conflit d'intérêts

RL received travel grants and/or conference speaker honoraria within the last 3 years from Bruker BioSpin MR, Heel, and support from Siemens Healthcare regarding clinical research using PET/MR. RL is a shareholder of the start-up company BM Health GmbH since 2019. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Petr Bednarik (P)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Institute for Clinical Molecular MRI in Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria.

Benjamin Spurny (B)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Leo R Silberbauer (LR)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Alena Svatkova (A)

Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.

Patricia A Handschuh (PA)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Birgit Reiter (B)

Clinical Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Melisande E Konadu (ME)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Thomas Stimpfl (T)

Clinical Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Marie Spies (M)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Wolfgang Bogner (W)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Institute for Clinical Molecular MRI in Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria.

Rupert Lanzenberger (R)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Classifications MeSH