Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen.
SARS-CoV-2
antivirals
plitidepsin
synergy
viral entry
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
12
2020
accepted:
01
02
2021
entrez:
12
4
2021
pubmed:
13
4
2021
medline:
13
4
2021
Statut:
epublish
Résumé
There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, their efficacy is still under evaluation. Here, we have screened existing drugs approved for human use in a variety of diseases, to compare how they counteract SARS-CoV-2-induced cytopathic effect and viral replication
Identifiants
pubmed: 33841165
doi: 10.3389/fphar.2021.646676
pii: 646676
pmc: PMC8033486
doi:
Types de publication
Journal Article
Langues
eng
Pagination
646676Informations de copyright
Copyright © 2021 Rodon, Muñoz-Basagoiti, Perez-Zsolt, Noguera-Julian, Paredes, Mateu, Quiñones, Perez, Erkizia, Blanco, Valencia, Guallar, Carrillo, Blanco, Segalés, Clotet, Vergara-Alert and Izquierdo-Useros.
Déclaration de conflit d'intérêts
A patent application based on this work has been filed (EP20382821.5). Unrelated to the submitted work, JB and JC are founders and shareholders of AlbaJuna Therapeutics, S.L. BC is founder and shareholder of AlbaJuna Therapeutics, S.L and AELIX Therapeutics, S.L. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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