Neutrophils in COVID-19.
COVID-19
SARS-CoV-2
clinical trials
granulocytes
neutrophils
scRNA-seq
viral infection
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
01
2021
accepted:
10
03
2021
entrez:
12
4
2021
pubmed:
13
4
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional and functional diversity as well as their developmental trajectories. These new findings are important to better understand the many facets of neutrophil involvement not only in COVID-19 but also many other acute or chronic inflammatory diseases, both communicable and non-communicable. Here, we highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophils and their reactivity in patients with COVID-19.
Identifiants
pubmed: 33841435
doi: 10.3389/fimmu.2021.652470
pmc: PMC8027077
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
652470Informations de copyright
Copyright © 2021 Reusch, De Domenico, Bonaguro, Schulte-Schrepping, Baßler, Schultze and Aschenbrenner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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