Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC).

Musashi-2 (MSI2) Non-small cell lung cancer (NSCLC) RNA binding proteins overall survival (OS) prediction biomarkers

Journal

Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916

Informations de publication

Date de publication:
Mar 2021
Historique:
entrez: 12 4 2021
pubmed: 13 4 2021
medline: 13 4 2021
Statut: ppublish

Résumé

Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation of numerous intracellular targets and influences maintenance of stem cell identity. This study assessed MSI2 as a potential clinical biomarker in non-small cell lung cancer (NSCLC). The current study included 40 patients with NSCLC, of whom one presented with stage 1, 14 presented with stage II, 15 presented with stage III, and 10 patients had stage IV. All patients received standard of care treatments. All patient samples were obtained before treatment started. We used immunohistochemical (IHC) approach to measure MSI2 protein expression in matching specimens of normal lung versus tumor tissues, and primary versus metastatic tumors, followed by correlative analysis in relation to clinical outcomes. In parallel, clinical correlative analysis of MSI2 mRNA expression was performed MSI2 protein expression in patient samples was significantly elevated in NSCLC primary tumors versus normal lung tissue (P=0.03). MSI2 elevated expression positively correlated with a decreased progression free survival (PFS) (P=0.026) combined for all stages and with overall survival (OS) at stage IV (P=0.013). Elevated MSI2 expression on RNA level was confirmed in primary tumor versus normal tissue samples in TCGA dataset (P<0.0001), and positively correlated with decreased OS (P=0.02). No correlation was observed between MSI2 expression and age, sex, smoking, and treatment type. Elevated MSI2 expression in primary NSCLC tumors is associated with poor prognosis and can be used as a novel potential prognostic biomarker in NSCLC patients. Future studies in an extended patient cohort are warranted.

Sections du résumé

BACKGROUND BACKGROUND
Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation of numerous intracellular targets and influences maintenance of stem cell identity. This study assessed MSI2 as a potential clinical biomarker in non-small cell lung cancer (NSCLC).
METHODS METHODS
The current study included 40 patients with NSCLC, of whom one presented with stage 1, 14 presented with stage II, 15 presented with stage III, and 10 patients had stage IV. All patients received standard of care treatments. All patient samples were obtained before treatment started. We used immunohistochemical (IHC) approach to measure MSI2 protein expression in matching specimens of normal lung versus tumor tissues, and primary versus metastatic tumors, followed by correlative analysis in relation to clinical outcomes. In parallel, clinical correlative analysis of MSI2 mRNA expression was performed
RESULTS RESULTS
MSI2 protein expression in patient samples was significantly elevated in NSCLC primary tumors versus normal lung tissue (P=0.03). MSI2 elevated expression positively correlated with a decreased progression free survival (PFS) (P=0.026) combined for all stages and with overall survival (OS) at stage IV (P=0.013). Elevated MSI2 expression on RNA level was confirmed in primary tumor versus normal tissue samples in TCGA dataset (P<0.0001), and positively correlated with decreased OS (P=0.02). No correlation was observed between MSI2 expression and age, sex, smoking, and treatment type.
CONCLUSIONS CONCLUSIONS
Elevated MSI2 expression in primary NSCLC tumors is associated with poor prognosis and can be used as a novel potential prognostic biomarker in NSCLC patients. Future studies in an extended patient cohort are warranted.

Identifiants

pubmed: 33841930
doi: 10.21037/jtd-20-2787
pii: jtd-13-03-1370
pmc: PMC8024834
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1370-1379

Subventions

Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218802
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA223394
Pays : United States

Informations de copyright

2021 Journal of Thoracic Disease. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-20-2787). The authors have no conflicts of interest to declare.

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Auteurs

Iuliia Topchu (I)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kazan Federal University, Kazan, Russian Federation.

Nikolai Karnaukhov (N)

National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Alexandra Mazitova (A)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kazan Federal University, Kazan, Russian Federation.

Veronika Yugai (V)

Kazan Federal University, Kazan, Russian Federation.

Mark Voloshin (M)

National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Mariya Tikhomirova (M)

Kazan Federal University, Kazan, Russian Federation.

Oleg Kit (O)

National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Elena Frantsiyants (E)

National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Leonid Kharin (L)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Tamara Airapetova (T)

National Medical Research Center of Oncology, Rostov-on-Don, Russia, Russian Federation.

Ekaterina Ratner (E)

Tatarstan Regional Clinical Cancer Center, Kazan, Russian Federation.

Alexey Sabirov (A)

Tatarstan Regional Clinical Cancer Center, Kazan, Russian Federation.

Zinaida Abramova (Z)

Kazan Federal University, Kazan, Russian Federation.

Iliya Serebriiskii (I)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kazan Federal University, Kazan, Russian Federation.

Yanis Boumber (Y)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kazan Federal University, Kazan, Russian Federation.
Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Alexander Deneka (A)

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kazan Federal University, Kazan, Russian Federation.

Classifications MeSH