Machine Perfusion of the Liver: A Review of Clinical Trials.
hypothermic liver perfusion
liver perfusion clinical trials
machine liver perfusion
machine perfusion clinical trials
normothermic liver perfusion
Journal
Frontiers in surgery
ISSN: 2296-875X
Titre abrégé: Front Surg
Pays: Switzerland
ID NLM: 101645127
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2020
accepted:
01
03
2021
entrez:
12
4
2021
pubmed:
13
4
2021
medline:
13
4
2021
Statut:
epublish
Résumé
Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft dysfunction and post-operative complications. Donor liver machine perfusion (MP) is a promising novel strategy that not only decreases cold ischemia time, but also serves as a method of assessing the viability of the graft. In this review, we summarize the data from liver machine perfusion clinical trials and discuss the various techniques available to date as well as future applications of machine perfusion. A variety of approaches have been reported including hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP); the advantages and disadvantages of each are just now beginning to be resolved. Important in this effort is developing markers of viability with lactate being the most predictive of graft functionality. The advent of machine perfusion has also permitted completely ischemia free transplantation by utilization of
Identifiants
pubmed: 33842530
doi: 10.3389/fsurg.2021.625394
pmc: PMC8033162
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
625394Subventions
Organisme : NIAID NIH HHS
ID : R25 AI147393
Pays : United States
Informations de copyright
Copyright © 2021 Serifis, Matheson, Cloonan, Rickert, Markmann and Coe.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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