Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores.
Journal
ACS applied polymer materials
ISSN: 2637-6105
Titre abrégé: ACS Appl Polym Mater
Pays: United States
ID NLM: 101734999
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
received:
21
10
2020
accepted:
25
12
2020
entrez:
12
4
2021
pubmed:
13
4
2021
medline:
13
4
2021
Statut:
ppublish
Résumé
A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H
Identifiants
pubmed: 33842888
doi: 10.1021/acsapm.0c01182
pmc: PMC8025732
doi:
Types de publication
Journal Article
Langues
eng
Pagination
588-593Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Acc Chem Res. 2013 Dec 17;46(12):2763-72
pubmed: 23537285
Chem Commun (Camb). 2008 Jul 14;(26):2986-8
pubmed: 18688323
Biochemistry. 1985 Jun 18;24(13):3091-8
pubmed: 4027231
Acc Chem Res. 2013 Dec 17;46(12):2781-90
pubmed: 23534613
Chem Commun (Camb). 2005 Mar 14;(10):1354-6
pubmed: 15742076
Curr Opin Cell Biol. 2001 Aug;13(4):405-11
pubmed: 11454444
Nano Lett. 2018 Apr 11;18(4):2738-2745
pubmed: 29569930
Nat Commun. 2020 Jan 24;11(1):469
pubmed: 31980608
Chem Soc Rev. 2007 Feb;36(2):378-89
pubmed: 17264938
Science. 2012 Nov 16;338(6109):890-1
pubmed: 23161982
Chem Commun (Camb). 2002 Dec 21;(24):3066-7
pubmed: 12536819
Chem Commun (Camb). 2013 Jan 4;49(1):19-29
pubmed: 23154531
Nature. 1994 May 26;369(6478):301-4
pubmed: 7514275
N Engl J Med. 1997 May 29;336(22):1575-86
pubmed: 9164815
J Am Chem Soc. 2001 Dec 12;123(49):12152-9
pubmed: 11734013
J Am Chem Soc. 2002 Feb 27;124(8):1615-9
pubmed: 11853434
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10520-10524
pubmed: 29900647
Nat Commun. 2018 Dec 7;9(1):5231
pubmed: 30531920