Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus.
Adolescent
Adult
Antigens, CD
/ metabolism
Antigens, Differentiation, Myelomonocytic
/ metabolism
Biomarkers, Tumor
/ metabolism
Child
Child, Preschool
Diagnosis, Differential
Epithelioid Cells
/ pathology
Factor XIIIa
/ metabolism
Female
Humans
Immunohistochemistry
/ methods
Infant
Lupus Erythematosus, Systemic
/ complications
Male
Microphthalmia-Associated Transcription Factor
/ metabolism
Middle Aged
Myxoma
/ pathology
Neprilysin
/ metabolism
Nervous System Neoplasms
/ pathology
Neurothekeoma
/ diagnosis
Skin Neoplasms
/ pathology
Ubiquitin Thiolesterase
/ metabolism
myxoid cellular neurothekeomas
systemic lupus erythematosus
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
24
03
2021
received:
11
01
2021
accepted:
06
04
2021
pubmed:
13
4
2021
medline:
27
11
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Cellular neurothekeoma is a cutaneous tumor with a distinctive histopathologic appearance characterized by a dermal-based multinodular proliferation of epithelioid to spindled cells. Although the tumor may show varying amounts of myxoid stroma, extensive myxoid change is uncommon. The tumor typically presents as a solitary nodule with a predilection for the head and neck and upper limbs; examples of multiple cellular neurothekeomas are decidedly rare. The present report describes a unique case of multiple myxoid cellular neurothekeomas arising in a 60-year-old female with systemic lupus erythematosus. Two papular lesions were identified involving the skin inferior to the umbilicus and the left inguinal crease. Both lesions were histopathologically similar, forming a nodular mass composed of epithelioid cells in a prominent myxoid stroma. By immunohistochemistry the lesional cells expressed NKI/C3, microphthalmia transcription factor (MiTF), and CD68, with focal staining for PGP9.5, factor XIIIa, and CD10 also observed. The tumors were negative for S-100, SOX-10, epithelial membrane antigen, desmin, smooth muscle actin, glial fibrillary acid protein, and CD34. The present case confirms that cellular neurothekeoma can present clinically as multiple lesions and can have a predominantly myxoid appearance, potentially mimicking other cutaneous myxoid lesions.
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
Biomarkers, Tumor
0
CD68 antigen, human
0
MITF protein, human
0
Microphthalmia-Associated Transcription Factor
0
UCHL1 protein, human
0
Factor XIIIa
EC 2.3.2.13
Ubiquitin Thiolesterase
EC 3.4.19.12
Neprilysin
EC 3.4.24.11
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-985Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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