Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.
Alzheimer Disease
/ drug therapy
Amyloid Precursor Protein Secretases
/ antagonists & inhibitors
Amyloid beta-Peptides
/ metabolism
Animals
Aspartic Acid Endopeptidases
/ antagonists & inhibitors
Binding Sites
Brain
/ metabolism
Crystallography, X-Ray
Dogs
Enzyme Inhibitors
/ chemical synthesis
Half-Life
Humans
Mice
Molecular Dynamics Simulation
Oxazines
/ chemistry
Picolinic Acids
/ chemical synthesis
Rats
Structure-Activity Relationship
Thiazines
/ chemical synthesis
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 04 2021
22 04 2021
Historique:
pubmed:
13
4
2021
medline:
16
6
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Starting from lead compound
Identifiants
pubmed: 33844524
doi: 10.1021/acs.jmedchem.0c02143
doi:
Substances chimiques
Amyloid beta-Peptides
0
Enzyme Inhibitors
0
NB-360
0
Oxazines
0
Picolinic Acids
0
Thiazines
0
Amyloid Precursor Protein Secretases
EC 3.4.-
Aspartic Acid Endopeptidases
EC 3.4.23.-
BACE2 protein, human
EC 3.4.23.45
BACE1 protein, human
EC 3.4.23.46
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM