Anti-SARS-CoV-2 Activity of

Andrographis Animals Cell Survival / drug effects Cells, Cultured Diterpenes / pharmacology Dose-Response Relationship, Drug Epithelial Cells / virology Humans Hydroxychloroquine / pharmacology Lung / virology Plant Extracts / pharmacology SARS-CoV-2 / drug effects

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
23 04 2021
Historique:
pubmed: 13 4 2021
medline: 5 5 2021
entrez: 12 4 2021
Statut: ppublish

Résumé

The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a major health problem, affecting more than 50 million people with over one million deaths globally. Effective antivirals are still lacking. Here, we optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of

Identifiants

DOI: 10.1021/acs.jnatprod.0c01324 PMID: 33844528
pubmed: 33844528
doi: 10.1021/acs.jnatprod.0c01324
doi:

Substances chimiques

Diterpenes 0
Plant Extracts 0
andrographolide 410105JHGR
Hydroxychloroquine 4QWG6N8QKH

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1261-1270

Auteurs

Khanit Sa-Ngiamsuntorn (K)

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
ORCID: 0000-0001-7010-345X

Ampa Suksatu (A)

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Yongyut Pewkliang (Y)

Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
ORCID: 0000-0003-2267-7883

Piyanoot Thongsri (P)

Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Phongthon Kanjanasirirat (P)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Suwimon Manopwisedjaroen (S)

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Sitthivut Charoensutthivarakul (S)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
School of Bioinnovation and Bio-Based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
ORCID: 0000-0002-4447-3438

Patompon Wongtrakoongate (P)

Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400,Thailand.

Supaporn Pitiporn (S)

ChaoPhya Abhaibhubejhr Hospital, Prachin Buri 25000, Thailand.

Jarinya Chaopreecha (J)

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Supasek Kongsomros (S)

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Kedchin Jearawuttanakul (K)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Warawuth Wannalo (W)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Phisit Khemawoot (P)

Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn 10540, Thailand.

Somchai Chutipongtanate (S)

Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn 10540, Thailand.
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Suparerk Borwornpinyo (S)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Arunee Thitithanyanont (A)

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Suradej Hongeng (S)

Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Acanthaceae › Andrographis › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Eucaryotes › Animaux › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Cellules › Cellules cultivées › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Cellules › Cellules épithéliales › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Chloroquine › Hydroxychloroquine › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Appareil respiratoire › Poumon › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Anti-SARS-CoV-2 Activity of
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Anti-SARS-CoV-2 Activity of