Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-

Animals Apoptosis / drug effects Binding Sites Biphenyl Compounds / chemistry Cell Differentiation / drug effects Cell Line, Tumor Dihydroorotate Dehydrogenase Drug Design Enzyme Inhibitors / chemistry Female Half-Life Humans Leukemia, Myeloid, Acute / drug therapy Male Mice Mice, Inbred BALB C Microsomes, Liver / metabolism Molecular Docking Simulation Oxidoreductases Acting on CH-CH Group Donors / antagonists & inhibitors Pyrazoles / chemistry Pyridines / chemistry Rats Rats, Sprague-Dawley Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 05 2021
Historique:
pubmed: 13 4 2021
medline: 17 6 2021
entrez: 12 4 2021
Statut: ppublish

Résumé

The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (

Identifiants

DOI: 10.1021/acs.jmedchem.0c01549 PMID: 33844533 PMC: PMC8279415
pubmed: 33844533
doi: 10.1021/acs.jmedchem.0c01549
pmc: PMC8279415
doi:

Substances chimiques

Biphenyl Compounds 0
Dihydroorotate Dehydrogenase 0
Enzyme Inhibitors 0
Pyrazoles 0
Pyridines 0
pyrazolo(3,4-b)pyridine 0
diphenyl 2L9GJK6MGN
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5404-5428

Références

J Med Chem. 2020 Feb 13;63(3):1388-1396
pubmed: 31939664
Expert Opin Ther Targets. 2018 Nov;22(11):893-898
pubmed: 30318938
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Cancer Res. 1985 Nov;45(11 Pt 1):5563-8
pubmed: 4053030
J Med Chem. 2012 Jun 14;55(11):5255-69
pubmed: 22587443
J Biol Chem. 2004 Aug 6;279(32):33035-8
pubmed: 15096496
J Med Chem. 2018 Feb 8;61(3):638-649
pubmed: 28745501
Medchemcomm. 2018 May 9;9(6):982-987
pubmed: 30108987
J Phys Chem B. 2017 Dec 14;121(49):11085-11095
pubmed: 29148803
Cancers (Basel). 2021 Feb 28;13(5):
pubmed: 33670894
ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117
pubmed: 27994748
J Phys Chem B. 2015 Jul 16;119(28):8693-7
pubmed: 26086954
Haematologica. 2019 Nov 07;105(9):2286-2297
pubmed: 33054053
Pharmacol Ther. 2019 Mar;195:111-131
pubmed: 30347213
Eur J Med Chem. 2017 Mar 31;129:287-302
pubmed: 28235702
J Comput Aided Mol Des. 2013 Mar;27(3):221-34
pubmed: 23579614
Eur J Med Chem. 2012 Mar;49:102-9
pubmed: 22245049
J Med Chem. 2019 May 9;62(9):4467-4482
pubmed: 30943028
Recent Pat Anticancer Drug Discov. 2018;13(1):86-105
pubmed: 29119937
Leukemia. 2019 Oct;33(10):2403-2415
pubmed: 30940908
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Virus Res. 2021 Jan 15;292:198246
pubmed: 33249060
Sci Rep. 2015 Oct 07;5:14836
pubmed: 26443076
Viruses. 2020 Sep 26;12(10):
pubmed: 32993173
Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17118-17129
pubmed: 31166642
Blood. 2010 Oct 28;116(17):3171-9
pubmed: 20644121
Cell. 2016 Sep 22;167(1):171-186.e15
pubmed: 27641501
ACS Med Chem Lett. 2019 Jan 28;10(4):437-443
pubmed: 30996776
Eur J Med Chem. 2019 Dec 1;183:111681
pubmed: 31557612
Eur J Med Chem. 2011 Jan;46(1):383-92
pubmed: 21109332
J Clin Oncol. 2017 Feb 20;35(6):605-612
pubmed: 27400939
Nat Rev Drug Discov. 2020 Mar;19(3):149-150
pubmed: 32127666
Sci Transl Med. 2018 May 23;10(442):
pubmed: 29794061
Antiviral Res. 2021 May;189:105057
pubmed: 33716051
J Med Chem. 2006 Feb 23;49(4):1239-47
pubmed: 16480261
J Mol Model. 2013 Mar;19(3):1099-107
pubmed: 23143678
Environ Sci Technol. 2014 Feb 18;48(4):2097-8
pubmed: 24476540
Lancet Oncol. 2015 Oct;16(13):1295-305
pubmed: 26384238
Eur J Clin Invest. 2020 Oct;50(10):e13366
pubmed: 32735689
Expert Opin Drug Discov. 2010 Mar;5(3):235-48
pubmed: 22823020
J Med Chem. 2018 Jul 26;61(14):6034-6055
pubmed: 29939742
Arch Biochem Biophys. 2017 Oct 15;632:175-191
pubmed: 28666740
J Med Chem. 2004 Mar 25;47(7):1750-9
pubmed: 15027866
J Med Chem. 1996 Sep 27;39(20):3920-8
pubmed: 8831758
Protein Cell. 2020 Oct;11(10):723-739
pubmed: 32754890
Viruses. 2020 Dec 05;12(12):
pubmed: 33291455
Eur J Med Chem. 2019 Feb 1;163:266-280
pubmed: 30529545
Medchemcomm. 2018 Apr 12;9(6):963-968
pubmed: 30108985
Medchemcomm. 2017 Aug 25;8(9):1850-1855
pubmed: 30108896

Auteurs

Stefano Sainas (S)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0001-5010-8536

Marta Giorgis (M)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0002-3282-1220

Paola Circosta (P)

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy.
ORCID: 0000-0001-8251-6905

Valentina Gaidano (V)

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
Division of Hematology, AO SS Antonio e Biagio e Cesare Arrigo, Via Venezia 16, Alessandria 15121, Italy.
ORCID: 0000-0003-0701-7975

Davide Bonanni (D)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0002-8832-0492

Agnese C Pippione (AC)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0003-3778-8420

Renzo Bagnati (R)

Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
ORCID: 0000-0002-6535-2686

Alice Passoni (A)

Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
ORCID: 0000-0001-6003-5932

Yaqi Qiu (Y)

Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy.
Higher Education Mega Center, Institutes for Life Sciences, South China University of Technology, Guangzhou 510641, China.
ORCID: 0000-0002-3135-7550

Carina Florina Cojocaru (CF)

Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy.
ORCID: 0000-0003-2340-6559

Barbara Canepa (B)

Gem Forlab srl, Via Ribes, 5, Colleretto Giacosa, Turin 10010, Italy.

Alessandro Bona (A)

Gem Chimica srl, Via Maestri del Lavoro, 25, Busca, Cuneo 12022, Italy.

Barbara Rolando (B)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0001-6138-1503

Mariia Mishina (M)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0003-2951-8789

Cristina Ramondetti (C)

Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
ORCID: 0000-0002-0501-5696

Barbara Buccinnà (B)

Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
ORCID: 0000-0002-5843-7112

Marco Piccinini (M)

Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
ORCID: 0000-0003-2287-0704

Mohammad Houshmand (M)

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy.
ORCID: 0000-0001-7503-6452

Alessandro Cignetti (A)

Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
ORCID: 0000-0003-2109-1194

Enrico Giraudo (E)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy.
ORCID: 0000-0003-4128-4786

Salam Al-Karadaghi (S)

Department of Biochemistry and Structural Biology, Lund University, Naturvetarvägen 14, Box 124, Lund 221 00, Sweden.
ORCID: 0000-0001-8608-0635

Donatella Boschi (D)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0003-4929-4460

Giuseppe Saglio (G)

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
ORCID: 0000-0002-1046-3514

Marco L Lolli (ML)

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
ORCID: 0000-0002-3030-3163

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydroorotate dehydrogenase › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Phénomènes physiques › Temps › Période › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Targeting Acute Myelogenous Leukemia Using...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Targeting Acute Myelogenous Leukemia Using...