Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts.
cohort
diet
epidemiology
pancreatic ductal adenocarcinoma
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
12 Apr 2021
12 Apr 2021
Historique:
revised:
17
03
2021
received:
27
10
2020
accepted:
19
03
2021
pubmed:
13
4
2021
medline:
13
4
2021
entrez:
12
4
2021
Statut:
aheadofprint
Résumé
There is limited evidence on the association between red meat consumption and pancreatic cancer among ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort-specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified via linkages to state cancer registries. Cox regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association of red meat intake with pancreatic cancer risk in each cohort. We performed additional analyses to evaluate cooking methods, mutagens and effect modification by NAT1/2 genotypes. From a total of 184 542 (MEC) and 66 793 (SCCS) at-risk participants, we identified 1618 (MEC) and 266 (SCCS) incident pancreatic cancer cases. Red meat consumption was associated with pancreatic cancer risk in the MEC (RR
Identifiants
pubmed: 33844845
doi: 10.1002/ijc.33598
pmc: PMC8594451
mid: NIHMS1743358
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : T32 CA229110
Pays : United States
Organisme : NCI NIH HHS
ID : U01CA202979
Pays : United States
Organisme : NCI NIH HHS
ID : U01CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA209798
Pays : United States
Organisme : NCI NIH HHS
ID : T32CA229110
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA236585
Pays : United States
Organisme : American Cancer Society
ID : RSG-16-250-01-CPHPS
Organisme : NCI NIH HHS
ID : R01 CA209798
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA202979
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : K99CA256525
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA256525
Pays : United States
Informations de copyright
© 2021 UICC.
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