Identification of conserved Mycoplasma agalactiae surface antigens by immunoproteomics.

Animals Antigens, Bacterial / immunology Antigens, Surface / isolation & purification Bacterial Proteins / classification Immunodominant Epitopes / classification Mycoplasma agalactiae / chemistry Proteome Proteomics / methods Sheep / immunology
Conserved antigens Contagious agalactia Immunodominant proteins Immunoproteomics Mycoplasma agalactiae

Journal

Veterinary immunology and immunopathology
ISSN: 1873-2534
Titre abrégé: Vet Immunol Immunopathol
Pays: Netherlands
ID NLM: 8002006

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 05 11 2020
revised: 16 03 2021
accepted: 02 04 2021
pubmed: 13 4 2021
medline: 8 10 2021
entrez: 12 4 2021
Statut: ppublish

Résumé

Contagious agalactia represents one of the most relevant infectious diseases of dairy sheep, with Mycoplasma agalactiae being the primary etiological agent. The early, sensitive, and specific identification of infected animals, as well as the development of efficient prophylactic tools, remain challenging. Here, we present a comprehensive characterization of M. agalactiae antigens focusing on those shared among different isolates. Leveraging on previous proteomic data obtained on individual strains, we adopted a strategy entailing sample pooling to optimize the identification of conserved proteins that induce an immune response. The liposoluble proteins from previously characterized field isolates and the type strain PG2

Identifiants

DOI: 10.1016/j.vetimm.2021.110239 PMID: 33845295
pubmed: 33845295
pii: S0165-2427(21)00057-X
doi: 10.1016/j.vetimm.2021.110239
pii:
doi:

Substances chimiques

Antigens, Bacterial 0
Antigens, Surface 0
Bacterial Proteins 0
Immunodominant Epitopes 0
Proteome 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110239

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Carla Cacciotto (C)

Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Italy; Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy; Porto Conte Ricerche Srl, Alghero, Italy.

Maria Filippa Addis (MF)

Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy; Porto Conte Ricerche Srl, Alghero, Italy; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Italy. Electronic address: filippa.addis@unimi.it.

Daniela Pagnozzi (D)

Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy.

Elisabetta Coradduzza (E)

Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Italy; Istituto Zooprofilattico Sperimentale della Sardegna "G. Pegreffi", Sassari, Italy.

Marco Pittau (M)

Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Italy; Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy.

Alberto Alberti (A)

Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Italy; Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy. Electronic address: alberti@uniss.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of conserved Mycoplasma...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Identification of conserved Mycoplasma...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Identification of conserved Mycoplasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Identification of conserved Mycoplasma...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Épitopes immunodominants › Identification of conserved Mycoplasma...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Tenericutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma agalactiae › Identification of conserved Mycoplasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Identification of conserved Mycoplasma...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Identification of conserved Mycoplasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Identification of conserved Mycoplasma...