Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer.
Alzheimer Disease
/ prevention & control
Amyloid beta-Peptides
Animals
Behavior, Animal
/ drug effects
Biomarkers
Cerebral Amyloid Angiopathy
/ prevention & control
Diet
Dietary Supplements
Encephalitis
/ prevention & control
Gliosis
/ prevention & control
Injections, Intraventricular
Male
Mice
Nonheme Iron Proteins
/ metabolism
Oxidative Stress
/ drug effects
Peptide Fragments
Psychomotor Performance
/ drug effects
Ribonucleotides
/ pharmacology
Alzheimer’s disease
Iron metabolism
Neuro-inflammation
Ribodiet®
Ribonucleotides
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
22
02
2021
revised:
29
03
2021
accepted:
31
03
2021
pubmed:
13
4
2021
medline:
27
7
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain. Additionally, increasing evidence demonstrates that a neuroinflammatory state and oxidative stress, iron-dependent, play a crucial role in the onset and disease progression. Besides conventional therapies, the use of natural-based products represents a future medical option for AD treatment and/or prevention. We, therefore, evaluated the effects of a ribonucleotides-based ingredient (Ribodiet®) in a non-genetic mouse model of AD. To this aim, mice were injected intracerebroventricularly (i.c.v.) with Aβ
Identifiants
pubmed: 33845375
pii: S0753-3322(21)00364-4
doi: 10.1016/j.biopha.2021.111579
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Nonheme Iron Proteins
0
Peptide Fragments
0
Ribonucleotides
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111579Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.