A Review of the Synthesis of Nitric Oxide Donor and Donor Derivatives with Pharmacological Activities.
NO donor
NO donor derivatives
free radical
mechanism
signal transduction molecule
synthetic route
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
10
2020
revised:
07
01
2021
accepted:
11
01
2021
pubmed:
14
4
2021
medline:
18
5
2022
entrez:
13
4
2021
Statut:
ppublish
Résumé
Endogenous nitric oxide (NO) is an important effector molecule and signal transduction molecule, which participates in the regulation of multiple functions in organisms, involving various a variety of physiological and pathological processes, especially playing a very important role in the cardiovascular, immune, and nervous systems. NO is a gaseous substance with a short half-life in the body and is unstable in aqueous solutions. Therefore, many researchers focus on the release and activity of NO donors and their derivatives. However, NO donors can release free NO or NO analogues under physiological conditions to meet the human need. NO donors can be coupled with the corresponding active basic nucleus, so that they have the biological activity derived from both the basic nucleus and the NO donors, thus performing better bioactivity. This paper reviewed the routes of synthesis and advance activities of NO donor derivatives.
Identifiants
pubmed: 33845741
pii: MRMC-EPUB-115307
doi: 10.2174/1389557521666210412161801
doi:
Substances chimiques
Nitric Oxide Donors
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
873-883Subventions
Organisme : Heilongjiang Postdoctoral Foundation
ID : LBH-Q15111
Organisme : Qing Miao Po Tu of Harbin Medical University, China
ID : 31021190046
Informations de copyright
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